摘要
目的探讨肿瘤标志物及细胞角蛋白19(CK-19)基因表达在乳腺癌诊断中的应用价值。方法选取本院2017年4月至2018年9月收治的50例乳腺癌患者作为试验组,另选取同期本院收治的60例乳腺良性肿瘤患者作为对照组,检测两组癌胚抗原(CEA)、糖类抗原153(CA153)、CK-19水平,以病理诊断为金标准,评估各项指标单项检测及联合检测乳腺癌灵敏度、特异度及准确度。结果试验组CEA(8.41±1.26)ng/ml、CA153(52.63±9.26)U/ml、CK-19(16.26±2.54)×102拷贝/ml均高于对照组[(2.65±1.32)ng/ml、(23.26±5.69)U/ml、(8.33±2.05)×102拷贝/ml],差异均有统计学意义(均P<0.05);CEA、CA153、CK-19单项检测阳性率分别为56.00%、70.00%、70.00%,均低于联合诊断检测阳性率的88.00%,差异均有统计学意义(均P<0.05);联合检测灵敏度88.00%、准确度90.00%、特异度89.09%均优于CEA(56.00%、63.33%、60.00%)、CA153(70.00%、68.33%、69.09%)、CK-19(70.00%、80.00%、75.45%)。结论肿瘤标志物及CK-19联合检测可提升乳腺癌诊断灵敏度、特异度及准确度,为临床诊断乳腺癌提供重要价值。
Objective To investigate the application value of tumor markers and cytokeratin 19(CK-19)gene expression in the diagnosis of breast cancer.Methods A total of 50 breast cancer patients admitted to our hospital from April 2017 to September 2018 were selected as the experimental group,and 60 patients with benign breast tumors admitted to our hospital were selected as the control group.The levels of carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153),and CK-19 of the two groups were detected.The sensitivity,specificity,and accuracy of individual indicators and combined detection in the diagnosis of breast cancer were evaluated with pathological diagnosis as the gold standard.Results The levels of CEA,CA153,and CK-19 in the experimental group were higher than those in the control group[(8.41±1.26)ng/ml vs.(2.65±1.32)ng/ml,(52.63±9.26)U/ml vs.(23.26±5.69)U/ml,(16.26±2.54)×102 copies/ml vs.(8.33±2.05)×102 copies/ml],with statistically significant differences(P<0.05).The positive rates of CEA,CA153,CK-19 single test were 56.00%,70.00%,70.00%respectively,which were lower than 88.00%of the combined detection,with statistically significant differences(P<0.05).The sensitivity,accuracy,and specificity of the combined detection(88.00%,90.00%,89.09%)were better than those of CEA(56.00%,63.33%,60.00%),CA153(70.00%,68.33%,69.09%),CK-19(70.00%,80.00%,75.45%).Conclusion Combined detection of tumor markers and CK-19 can improve the diagnostic sensitivity,specificity,and accuracy of breast cancer,and provide important value for clinical diagnosis of breast cancer.
作者
石岩
肖继辉
Shi Yan;Xiao Jihui(Department of Pathology,Linyi County People's Hospital,Luohe 462600,China)
出处
《国际医药卫生导报》
2019年第24期4073-4075,共3页
International Medicine and Health Guidance News
