摘要
生长分化因子-15(GDF-15)是转化生长因子-β超家族成员的一种应激蛋白,已证实是冠心病、心力衰竭等心血管疾病的标志物。近年研究发现GDF-15在心房颤动人群中表达升高,并对预后具有一定预测作用;然而,具体作用和机制未明。现对GDF-15在心房颤动发生和发展中的研究进展做一综述。
Growth differentiation factor 15(GDF-15)is a stress-responsive protein that belongs to the super family of transforming growth factorβ.It has been proved to be a biomarker in cardiovascular diseases,such as coronary heart disease and heart failure.Recently,the GDF-15 concentrations were reported to be higher in patients with atrial fibrillation,and can possibly be used as its prognostic indicator.But the specific mechanisms remain unclear.In this article,we review the recent studies that discussed the research advancement of GDF-15 in the development of atrial fibrillation.
作者
韦莹
刘书旺
李蕾
崔鸣
WEI Ying;LIU Shuwang;LI Lei;CUI Ming(Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China)
出处
《心血管病学进展》
CAS
2019年第8期1073-1077,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(31700674)
关键词
生长分化因子-15
心房颤动
心血管疾病
Growth differentiation factor 15
Atrial fibrillation
Cardiovascular diseases
