摘要
目的:分析复方氟米松联合卡泊三醇软膏与UVA1光疗治疗甲银屑病的疗效及不良反应。方法:收集88例甲银屑病患者随机分成两组,每组各44例,单一组予以卡泊三醇软膏与UVA1光疗治疗,联合组予以复方氟米松联合卡泊三醇软膏与UVA1光疗治疗,治疗3个月。比较两组甲严重程度指数、相关细胞因子、转录因子mRNA表达情况、生活质量以及不良发应发生的变化情况。结果:NAPSI组间、时间、交互比较均存在显著差异(P<0.05),治疗1个月、3个月,联合组NAPSI评分显著低于单一组(P<0.05),两组治疗1个月、3个月NAPSI评分依次显著降低(P<0.05);治疗后,联合组IL-17、IL-22、IL-10、INF-γ变化幅度大于单一组(P<0.05);治疗后,联合组RORγt、STAT3 mRNA表达下调幅度大于单一组(P<0.05);治疗后,联合组DLQI评分下降幅度大于单一组(P<0.05);治疗期间两组不良反应发生率比较差异不显著(P>0.05)。结论:复方氟米松联合卡泊三醇软膏与UVA1光疗治疗甲银屑病,可有效改善患者临床症状,调节血清相关细胞因子水平,下调转录因子mRNA表达,提高患者生活质量。
Objective: To analyze the efficacy and adverse reactions of compound flumetasone combined with calcipotriol ointment and UVA1 phototherapy in the treatment of nail psoriasis. Methods: 88 patients with nail psoriasis were collected and randomly divided into two groups,with 44 cases in each group. Single group was given calcipotriol ointment and UVA1 phototherapy, and combined group was given compound flumetasone combined with calcipotriol ointment and UVA1 phototherapy, and they were treated for 3 months. The nail severity index, related cytokines, transcription factor mRNA expression, quality of life, and occurrence of adverse reactions were compared between the two groups. Results:There were significant differences in group effects, time effects and interaction effects of NAPSI(P<0.05), and the NAPSI scores in combined group at 1 month and 3 months of treatment were significantly lower than those in single group(P<0.05), and the NAPSI scores in the two groups at 1 month and 3 months of treatment were significantly decreased successively(P<0.05). After treatment, the changes of IL-17, IL-22, IL-10 and INF-γ in combined group were larger than those in single group(P<0.05). After treatment, the decreases of mRNA expressions of RORγt and STAT3 in combined group were greater than those in single group(P<0.05). After treatment, the decrease of DLQI score in combined group was greater than that in single group(P<0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups during treatment(P>0.05). Conclusion:Compound flumetasone combined with calcipotriol ointment and UVA1 phototherapy for nail psoriasis can effectively improve clinical symptoms, regulate serum-related cytokines levels, down-regulate mRNA expressions of transcription factors, and improve quality of life of patients.
作者
孙田
王强
王东
SUN Tian;WANG Qiang;WANG Dong(Shenyang Seventh People's Hospital, Liaoning Shenyang 110003, China)
出处
《河北医学》
CAS
2019年第12期2067-2071,共5页
Hebei Medicine
基金
辽宁省科技攻关计划项目,(编号:201536810H42)
