摘要
目的研究多巴胺联合厄贝沙坦治疗肺纤维化并肾功能不全的效果。方法58例肺纤维化并肾功能不全患者,根据治疗方式不同分为对照组与研究组,各29例。对照组单独采取多巴胺治疗,研究组在对照组基础上采取厄贝沙坦治疗,观察比较两组患者治疗效果、不良反应发生情况及血肌酐(Scr)、尿素氮(BUN)、胱抑素C(Cys-C)指标。结果研究组治疗总有效率93.10%高于对照组的68.97%,差异有统计学意义(P<0.05)。治疗2周、随访3个月、随访6个月研究组Scr分别为(315.41±53.05)、(275.65±30.52)、(145.15±20.47)μmol/L,BUN分别为(7.01±1.22)、(6.25±1.05)、(5.48±1.22)mmol/L,Cys-C分别为(1.41±0.12)、(1.08±0.11)、(1.01±0.05)mg/L;对照组Scr分别为(345.54±55.54)、(356.63±58.85)、(345.41±50.69)μmol/L,BUN分别为(7.61±1.36)、(7.05±1.21)、(8.51±1.35)mmol/L,Cys-C分别为(1.61±0.19)、(1.25±0.16)、(1.09±0.15)mg/L。治疗2周、随访3个月、随访6个月研究组Scr、BUN、Cys-C均低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率10.34%低于对照组的34.48%,差异有统计学意义(P<0.05)。结论对于肺纤维化并肾功能不全患者,可采取多巴胺联合厄贝沙坦治疗,患者肾功能明显好转,且疗效较为显著,值得应用。
Objective To study the effect of dopamine combined with irbesartan in the treatment of pulmonary fibrosis and renal insufficiency.Methods A total of 58 patients with pulmonary fibrosis and renal insufficiency were divided into control group and research group,with 29 cases in each group.The control group was treated by dopamine,and the research group was treated by irbesartan on the basis of the control group.The therapeutic effect,occurrence of adverse reactions,serum creatinine(SCR),blood urea nitrogen(BUN),Cystatin C(Cys-C)was observed and compared between the two groups.Results The total effective rate of treatment 93.10%in the research group was higher than 68.97%in the control group,and the difference was statistically significant(P<0.05).After 2 months of treatment,3 and 6 months of follow-up,the Scr were(315.41±53.05),(275.65±30.52)and(145.15±20.47)μmol/L respectively in the research group,BUN were(7.01±1.22),(6.25±1.05)and(5.48±1.22)mmol/L respectively,Cys-C were(1.41±0.12),(1.08±0.11)and(1.01±0.05)mg/L respectively.The Scr were(345.54±55.54),(356.63±58.85)and(345.41±50.69)μmol/L respectively in the control group,BUN were(7.61±1.36),(7.05±1.21)and(8.51±1.35)mmol/L respectively,and Cys-C was(1.61±0.19),(1.25±0.16)and(1.09±0.15)mg/L respectively.After 2 months of treatment,3 and 6 months of follow-up,the Scr,BUN and Cys-C in the research group was lower than those in the control group,and their difference was statistically significant(P<0.05).The incidence of adverse reactions 10.34%in the research group was lower than 34.48%in the control group,and the difference was statistically significant(P<0.05).Conclusion Dopamine combined with irbesartan shows remarkable efficacy in the treatment of patients with pulmonary fibrosis and renal insufficiency,and the renal function of patients was obviously improved.It is worthy of application.
作者
周雪
高淑艳
李珊
高福泉
ZHOU Xue;GAO Shu-yan;LI Shan(Department of Respiratory and Critical Medicine,Binzhou Medical University Affiliated Hospital,Binzhou 256603,China)
出处
《中国实用医药》
2019年第36期3-5,共3页
China Practical Medicine
基金
山东省医药卫生科技发展计划项目(项目编号:2014WS0190)
关键词
多巴胺
厄贝沙坦
肺纤维化
肾功能不全
Dopamine
Irbesartan
Pulmonary fibrosis
Renal insufficiency
