摘要
目的探讨青少年性发育异常患者血清25-羟维生素D水平和骨密度的关系。方法选择温州市人民医院2015年1月至2019年3月收治的35例性发育异常(DSD)的青少年作为观察组,以同期健康体检结果正常的青少年38例作为对照组,检测并对比不同类型性发育异常患者血清25-羟维生素D水平、骨密度T值及两者之间的关系。结果 (46,XX DSD)组、(46,XY DSD)组、(性染色体异常DSD)组和对照组血清25-羟维生素D、骨密度T值比较差异均有统计学意义(F值分别为5.614、8.374,均P<0.05),进一步每两组间比较结果显示(46,XX DSD)组、(46,XY DSD)组、(性染色体异常DSD)组血清25-羟维生素D均显著低于对照组(t值分别为3.263、3.122、3.314,均P<0.05),骨密度T值均显著低于对照组(t值分别为3.196、2.998、3.295,均P<0.05),(46,XX DSD)组、(46,XY DSD)组、(性染色体异常DSD)组三组每两组之间比较血清25-羟维生素D水平、骨密度T值差异均无统计学意义(t=0.144~2.016,均P>0.05)。血清25-羟维生素D的不同缺乏程度下DSD患者骨密度T值的比较差异有统计学意义(F=4.325,P<0.05),进一步每两组间比较差异均有统计学意义(t=3.012~6.392,均P<0.05),DSD患者25-羟维生素D水平越低,其骨密度T值越低。结论青少年性发育异常患者体内多有维生素D不足和缺乏状况,其维生素D越低其骨密度越低,可为临床上性发育异常患者补充维生素D、防治骨质疏松症、缓解临床症状提供参考。
Objective To investigate the relationship between serum 25-hydroxyvitamin D levels and bone mineral density in adolescents with sexual dysplasia(DSD).Methods A total of 35 patients with sexual dysplasia admitted to our hospital during the period from January 2015 to March 2019 were enrolled in this observation group,and 38 normal cases during the same period comprised the control group.25-hydroxyvitamin D serum levels of them with different types of sexual dysplasia bone density T value and the relationship between them were analyzed.Result There were significant differences in serum 25-hydroxyvitamin D and bone mineral density T values between(46,XX DSD) group,(46,XY DSD) group,(sex chromosome abnormality DSD) group and control group(F=5.614,8.374,P<0.05 for all).Further comparisons showed that(46,XX DSD) group,(46,XY DSD) group,(sex chromosome abnormality DSD) group showed a lower serum 25-hydroxyvitamin D levels compared with the control group(t=3.263,3.122,3.314,respectively,P<0.05 for all),and bone mineral density T values were significantly lower than those in control group(t=3.196,2.998,3.295,respectively,P<0.05 for all).There was no significant difference in serum 25-hydroxyvitamin D level and bone mineral density T value between the two groups(t=0.144-2.016,P>0.05).There was a significant difference in bone mineral density(BMD) T value between DSD patients with different levels of serum 25-hydroxyvitamin D deficiency(F=4.325,P<0.05).Further,there was a significant difference for each two groups(t=3.012-6.392,P<0.05 for all).The lower the level of 25-hydroxyvitamin D in DSD patients,the lower the BMD T value.Conclusion Vitamin D deficiency and deficiency in adolescents with sexual dysplasia.The lower the vitamin D,the lower the bone density,and the vitamin D can be supplemented for patients with clinical sexual dysplasia.This research can provide reference for osteoporosis and reducing clinical symptoms.
作者
潘秋飞
张宇
PAN Qiufei;ZHANG Yu(Department Of Child Healthcare,Wenzhou People's Hospital,Wenzhou 325000,Zhejiang,China)
出处
《中国妇幼健康研究》
2019年第11期1400-1403,共4页
Chinese Journal of Woman and Child Health Research
