摘要
目的通过分析偏头痛患者Willis环不完整性的发生率,探讨偏头痛发病的可能机制。方法收集自2014年1月至2019年2月南京脑科医院神经内科诊治的偏头痛患者191例,其中先兆偏头痛(MA)患者58例(男20/女38),无先兆偏头痛(MOA)患者133例(男43/女90),同时纳入年龄性别相匹配的健康体检者85名(男29/女56),采集所有受试者头颅MRA资料,对各组间Willis环的不完整性发生率进行比较。结果偏头痛组Willis环的不完整性发生率(56.54%)显著高于对照组(40.00%),MA组(60.34%)与MOA(54.14%)组Willis环的不完整性发生率比较无统计学差异;亚组分析发现,偏头痛组Willis环前部不完整性发生率(16.23%)与对照组(15.29%)相比无统计学差异,Willis环后部不完整性发生率(47.64%)较对照组(32.94%)显著增高(P<0.05),MA组Willis环前部不完整性发生率(18.97%)与MOA组(15.04%)及对照组(15.29%)比较均无统计学差异,MA组(51.72%)及MOA组(46.61%)Willis环后部不完整性发生率较对照组(32.94%)均显著增高(均P<0.05),MA组Willis环后部不完整性与MOA组相比无统计学差异。结论 Willis环的不完整性与偏头痛的发病存在一定相关性,是偏头痛发病可能病因。
Objective To investigate the possible mechanism of migraine by analyzing the incidence of incomplete circle of Willis in migraine patients. Methods A total of 191 migraine patients from the Department of Neurology, Nanjing Brain Hospital from January 2014 to February 2019 were enrolled, including 58 patients with migraine with auro(MA)(male 20/female 38) and 133 patients with migraine without auro(MOA)(male 43/female 90). Eigty-five healthy subjects(male 29/female 56) were included. Brain MRA of all subjects were collected to analyze the incidence of incomplete circle of Willis between groups.Results The incidence of incomplete circle of Willis in the migraine group(56.54%) was significantly higher than that in the control group(40.00%). There was no significant difference in the incidence of incompletecircle of Willis inthe migraine group(60.34%) and the control group(54.14%). There was no significant difference in the incidence of incomplete anterior portion circle of Willis between the migraine group(16.23%)and the control group(15.29%). The incidence of incomplete posterior portion circle of Willis in migraine group(47.64%) was significantly higher than that of the control group(32.94%)(P<0.05). There was no significant difference in the incidence of incomplete anterior portion circle of Willis inMA group(18.97%), MOA group(15.04%) and the control group(15.29%). The incidence of incomplete posterior portion circle of Willis in MA group(51.72%) and MOA group(46.61%) was significantly higher than that in the control group(32.94%)(allP<0.05). There was no significant difference in the incidence of incomplete posterior portioncircle of Willis in the MA group andthe MOA group.Conclusions There is a certain correlation between the incomplete circle of Willis and the incidence of migraine. It is a possible cause of migraine.
作者
余传勇
黄琳
YU Chuan-yong;HUANG Lin(Department of Neurologyt Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China)
出处
《临床神经病学杂志》
CAS
2019年第6期423-425,共3页
Journal of Clinical Neurology
基金
南京医科大学科技发展基金面上项目(2014NJMU052)
