摘要
目的比较同步放化疗和放疗序贯化疗治疗非小细胞肺癌骨转移的临床疗效和安全性。方法回顾性分析2013年6月至2018年6月我院收治的120例非小细胞肺癌骨转移患者的临床资料,其中60例行同步放化疗,60例行放疗序贯化疗。比较两组骨痛缓解情况、近期疗效和不良反应发生情况。结果同步放化疗组患者治疗1个月、治疗2个月和治疗结束后1个月时的疼痛缓解率与序贯治疗组比较差异无统计学意义(P>0.05)。两组患者客观缓解率(50.0%和36.7%)和疾病控制率(90.0%和83.3%)比较差异无统计学意义(χ2=2.172和1.154,P=0.141和0.283)。同步放化疗组中性粒细胞减少(90.0%和60.0%)、白细胞减少(96.7%和63.3%)、恶心(50.0%和23.0%)等不良反应发生率高于序贯治疗组(χ2=14.400和20.833和9.187,均P<0.05),两组血小板减少、呕吐、乏力、脱发等不良反应发生率比较差异无统计学意义(P>0.05)。结论同步放化疗与放疗序贯化疗治疗非小细胞肺癌骨转移近期疗效接近,均可及早改善患者骨痛,但不良反应发生率较高。
Objective To compare the clinical efficacy and safety of concurrent chemoradiotherapy and sequential chemoradiotherapy for bone metastasis of non-small cell lung cancer(NSCLC).Methods This was a retrospective cohort study,in which 120 patients with bone metastases from NSCLC admitted to our hospital from June 2013 to June 2018 were enrolled.Of these patients,60 received sequential chemotheradiotherapy and 60 patients received concurrent chemoradiotherapy.Bone pain was measured before treatment,at 1-month,2-months into treatment,and 1-month after treatment.Short-term efficacy and adverse reactions were compared between the two groups.Results There were no significant differences in pain relief rate at 1-month,2-months into treatment and 1-month after treatment between the two groups(all P>0.05).Meanwhile,the objective response rate(50.0%vs.36.7%)and disease control rate(90.0%vs.83.3%)were also similar between the two groups(χ2=2.172,1.154,P=0.141,0.283).The incidences of toxic and side effects,including neutropenia(90.0%vs.60.0%),leukopenia(96.7%vs.63.3%)and nausea(50.0%vs.23.0%)were significantly higher in the concurrent chemoradiotherapy group than those in the sequential chemotherapy/radiotherapy group(all P<0.05).However,the rates of other toxic and side effects such as thrombocytopenia,vomiting,fatigue and alopecia were comparable between the two groups(all P>0.05).Conclusions Compared with sequential chemoradiotherapy,concurrent chemoradiotherapy has similar short-term efficacy in pain relief for bone metastasis of NSCLC,but the incidence of side effects is higher.
作者
潘文斌
何伟岳
Pan Wenbin;He Weiyue
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2019年第12期1353-1356,共4页
Chinese Journal of Geriatrics
关键词
癌
非小细胞肺
肿瘤转移
放射疗法
Carcinoma
non-small cell lung
Neoplasm metastasis
Radiotherapy
