摘要
[目的]优选酒洗红花的最佳炮制工艺,明确工艺参数,为酒洗红花的科学研究提供实验依据。[方法]采用正交实验以羟基红花黄色素A及山奈素为指标,考察加酒量、浸吸时间和烘干温度对酒洗红花炮制工艺的影响,并对其炮制前后的含量差异及其水煎液指纹图谱进行对比。[结果]最终确定较佳的酒洗方法为:加酒量为50%(每100 g药材加50 g黄酒),浸吸时间30 min,烘干温度40℃。炮制后羟基红花黄色素A与山奈素含量较生品降低,但差异较小;水煎液指纹图谱中大多数成分峰面积降低,小极性成分降低更明显。[结论]优选的酒洗红花炮制工艺有较好的可行性和可控性,适用于工业化生产。
[Objective] To select the best processing method and parametersof safflower prepared with liquor,and thenprovide the basis for Scientific research. [Methods] The orthogonal experiment was carried out with hydroxysafflor yellow A and kaempferol as indicators.the effects of alcohol content,soaking time and drying temperature were investigatedon the processing of wine-washed safflower. The difference in content and fingerprint of water decoction were compared before and after processing. [Results] The best process parameters were as follows:the amount of alcohol is 50%(50 g wine per 100 g of medicine),soaking time is 30 min,and baking temperature is40 ℃. After processing,the content of hydroxysafflor yellow A and kaempferol was lower than that in raw product,but the difference was small,the peak areas of most components in the decoction fingerprint were decreased,especially of the small polar components. [Conclusion] The preferred wine-washed safflower processing technology has good feasibility and good controllability,and is suitable for industrial production.
作者
刘彩凤
梁军
钟琳瑛
张琦
田湾湾
刘冬涵
白洁
杜守颖
何枢衡
LIU Caifeng;LIANG Jun;ZHONG Linying;ZHANG Qi;TIAN Wanwan;LIU Donghan;BAI Jie;DU Shouying;HE Shuheng(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;Yifan Pharmaceutical Co.,Ltd.,Lin'an 311300,China)
出处
《天津中医药大学学报》
CAS
2019年第6期593-597,共5页
Journal of Tianjin University of Traditional Chinese Medicine
基金
经典名方易黄汤、固本止崩汤颗粒剂的合作开发研究(2020071720253)
北京市优秀人才培养资助青年骨干教师项目(201600002012G076)
关键词
酒洗红花
正交设计
炮制工艺
含量测定
指纹图谱
wine-washed safflower
orthogonaldesign
processing technology
content determination
fingerprint
