摘要
目的了解蒿芩清胆汤联合血府逐瘀胶囊对盆腔炎疾病所致痛经患者血清辅助性T细胞1(Th1)/Th2和粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平的影响。方法选取某院收治的80例盆腔炎疾病所致痛经患者,随机分为对照组和观察组,每组40例。对照组给予血府逐瘀胶囊治疗,观察组给予蒿芩清胆汤联合血府逐瘀胶囊治疗,比较两组治疗前后中医症候积分、局部体征评分、血清白细胞介素2(IL-2)、γ干扰素(IFN-γ)、IL-4、IL-10、Th1/Th2、GMCSF水平。结果与治疗前相比,治疗后两组中医症候积分、局部体征评分均降低,且观察组降低幅度大于对照组(P<0.01);观察组治疗后IL-2、IFN-γ、Th1/Th2低于对照组,IL-4、IL-10高于对照组(P<0.01);与治疗前相比,两组治疗后血清GM-CSF水平均降低,且观察组降低幅度大于对照组(P<0.01)。结论蒿芩清胆汤联合血府逐瘀胶囊治疗盆腔炎疾病所致痛经,可有效缓解患者痛经、月经异常等症状,调节患者免疫功能,改善炎症状态。
Objective To analyze the effect Haoqin gallbladder-clearing decoction combined with Xuefu Zhuyu Capsules on the serum level of helper T cell 1(Th1)/Th2 and granulocyte-macrophage colony stimulating factor(GM-CSF) in patients with dysmenorrhea caused by pelvic inflammatory disease. Methods A total of 80 patients with dysmenorrhea caused by pelvic inflammatory disease treated in a hospital were selected and randomly divided into the Control Group and Observation Group, 40 cases in each group. The Control Group was administered with Xuefu Zhuyu Capsules while the Observation Group was administered with Haoqin gallbladder-clearing decoction combined with Xuefu Zhuyu Capsules. The two groups were compared before and after treatment in terms of TCM symptom score, local sign score and the level of IL-2, IFN-γ, IL-4, IL-10, Th1/Th2 and GM-CSF. Results Both groups had the TCM symptom score and local sign score decreased compared with those before the treatment, and the Observation Group showed a greater decrease than the Control Group(P<0.01). The Observation Group had the serum levels of IL-2, IFN-γ and Th1/Th2 lower than the Control Group and the serum levels of IL-4 and IL-10 higher than the Control Group after the treatment(P<0.01). Compared with that before the treatment, both groups had the serum level of GM-CSF decreased, and the Observation Group showed a greater decrease than the Control Group(P<0.01). Conclusion Haoqin gallbladder-clearing decoction combined with Xuefu Zhuyu Capsules can effectively relieve the symptoms and signs of patients such as dysmenorrhea and abnormal menstruation, regulate the immune function of patients and improve the inflammatory state of patients in the treatment of dysmenorrhea caused by pelvic inflammatory disease.
作者
谭志平
陈观尚
林玲莉
TAN Zhi-ping;CHEN Guan-shang;LIN Ling-li(The Zhanjiang Second Hospital of Traditional Chinese Medicine,Zhanjiang 524013,China)
出处
《广东医科大学学报》
2019年第6期647-650,共4页
Journal of Guangdong Medical University
关键词
蒿芩清胆汤
血府逐瘀胶囊
GM-CSF
盆腔炎疾病
痛经
TH1/TH2
Haoqin gallbladder-clearing decoction
Xuefu Zhuyu capsules
GM-CSF
pelvic inflammation disease
dysmenorrhea
Th1/Th2
