摘要
目的了解庆阳市育龄妇女麻疹病毒(MV)、风疹病毒(RV)、巨细胞病毒(CMV)、人类单纯疱疹病毒1+2(HSV1+2)4项病毒抗体水平及含麻疹和风疹成分疫苗的接种情况,为孕前保健措施的制定提供依据。方法收集2016-01/2019-01在庆阳市人民医院进行产前检查的3210例育龄期妇女血清标本,采用酶联免疫法对MV、RV、CMV及HSV(1+2)进行抗体检测,采用Excel 2007和SPSS 22.0软件对数据进行整理分析,率的比较采用χ2检验,以P<0.05有统计学意义。结果3210例育龄妇女血清抗体检测结果显示,IgM抗体检出阳性率最高的是HSV(1+2)-IgM,阳性率为6.26%,IgG抗体阳性检出率最高的是CMV-IgG,阳性率为90.5%。RV-IgM,CMV-IgM和HSV(1+2)-IgM抗体阳性检出率在不同年龄组间差异均无统计学意义(P<0.05)。RV-IgM,CMV-IgM和HSV(1+2)-IgM抗体阳性检出率均在春季较高,RV-IgM和CMV-IgM抗体在不同季节阳性检出率差异有统计学意义(P<0.05)。对含MV和RV成分疫苗有明确接种史的人口所占比例均较低,分别为10.59%和14.74%,有明确接种史的人群中城镇人口高于农村,且不同户籍接种情况差异有统计学意义(P<0.05)。结论庆阳地区育龄妇女4项病毒感染率较高,对含MV及RV成分疫苗接种率低,应加大对育龄妇女孕前及孕期传染病的检测力度,积极采取预防措施,降低有缺陷新生儿的出生,提高本地区人口素质。
Objective To understand the level of antibodies of measles virus(MV),rubella virus(RV),cytomegalovirus(CMV)and herpes simplex virus 1+2(HSV1+2)and the vaccination of measles and rubella containing vaccines in the women of childbearing age in Qingyang City,in order to provide evidence for pre-pregnancy health care measures.Methods This study collected 3210 serum specimens from 3210 women of childbearing age who underwent the prenatal check from January 2016 to January 2019 in Qingyang people’s hospital,all the serum specimens were detected in the antibodies of MV,RV,CMV and HSV(1+2)of by enzyme-linked immunosorbent assay.The data was sorted out and analyzed by Excel 2007 and SPSS 22.0,and chi-square test was used to compare the rates,P<0.05 means the difference was statistically significant.Results The antibody test results of the serum specimens from 3210 women of childbearing age indicated that,HSV(1+2)-IgM had the highest positive rate in IgM antibodies,with a positive rate of 6.26%,CMVIgG had the highest positive rate in IgG antibodies(90.5%).The positive rate of RV-IgM,CMVIgM and HSV(1+2)-IgM antibodies had no statistical difference in different age groups(P>0.05).The positive rate of RV-IgM,CMV-IgM and HSV(1+2)-IgM antibodies were higher in spring,the positive rate of the RV-IgM and CMV-IgM antibodies showed statistical difference in different seasons(P<0.05).The population who had vaccinated the vaccines containing MV and RV ingredients accounted for a lower proportion of 10.59% and 14.74%,respectively.Among them,the number of urban residents was higher than that of rural residents,and the vaccination of population with different household registration was statistically significant(P<0.05).Conclusion In Qingyang,the infection rate of the above four viruses in the women of childbearing age is relatively high,and the vaccination rate of the vaccines containing MV and RV ingredients remains low.Detection of infectious diseases before and during pregnancy of women of childbearing age should be strengthened,ac
作者
侯怀哲
朱圭娜
尚宇翔
张吉平
HOU Huaizhe;ZHU Guina;SHANG Yuxiang;ZHANG Jiping(Laboratory Department of Qingyang People’s Hospital,Qingyang 745000,Gansu Province,China;Qingyang Center for Disease Control and Prevention,Qingyang 745000,Gansu Province,China)
出处
《职业卫生与病伤》
2019年第6期375-379,共5页
Occupational Health and Damage
关键词
育龄妇女
麻疹病毒
风疹病毒
巨细胞病毒
单纯疱疹病毒
抗体水平
疫苗接种
women of childbearing age
measles virus
rubella virus
cytomegalovirus
herpes simplex virus
level of antibody
vaccination
