摘要
目的探讨机械功(MP)监测对ICU中重度急性呼吸窘迫综合征(ARDS)患者肺复张潜能的评估价值及患者28 d生存状态的预测价值。方法选择2017年4月至2019年4月连云港市第一人民医院重症医学科收治机械通气时间超过24 h的中重度ARDS患者,根据病情对其实施肺复张(RM)治疗,并监测RM前及RM后1小时的机械功、肺部超声评分(LUS)、氧合指数(P/F)及死腔容积比率(Vd/Vt)。根据患者RM前后再通气评分变异ΔLUS是否大于5分将患者分为肺复张潜能阳性组(RMP-P组)及肺复张潜能阴性组(RMP-N组),比较两组RM前后机械功差异。分析患者RM前后机械功变异(ΔMP)、再通气评分变异(ΔLUS)、氧合指数变异(ΔP/F)及死腔容积比率变异(ΔVd/Vt)相关性。采用受试者工作特征曲线(ROC)分析ΔMP对ARDS患者肺复张潜能及28 d生存状态的预测价值。结果入组83例患者,RMP-P组45例,RMP-N组38例,两组基线水平差异无统计学意义(均P>0.05);两组患者经RM治疗后自身前后对比,MP、LUS评分及Vd/Vt均显著下降,P/F显著升高(均P<0.05),治疗后组间比较RMP-P组MP、LUS评分及Vd/Vt均显著低于RMP-N组(均P<0.05),而两组间P/F差异无统计学意义(P>0.05);RMP-P组RM后ΔMP,ΔLUS及ΔVd/Vt,显著高于RMP-N组(均P<0.05),两组间ΔP/F比较差异无统计学意义(P>0.05);相关性分析显示ΔMP与ΔLUS及ΔVd/Vt呈显著正相关(r分别为0.4746,0.3995,均P<0.01),与ΔP/F无明显相关性(r=0.0314,P>0.05);ΔMP预测ARDS患者肺复张潜能曲线下面积(AUC)0.856,敏感度为91.1%,特异度为63.2%;预测28 d生存状态的AUC为0.788,敏感度为84.3%,特异度为62.5%(均P<0.05)。结论中重度ARDS患者肺复张前后机械功监测对评估肺复张潜能具有一定的临床价值,对ARDS患者28 d生存具有一定预测价值。
Objective To investigate the value of mechanical power(MP)to predict the potential of the lung recruitment maneuver and assess prognoses in patients with acute respiratory distress syndrome(ARDS).Methods Patients with moderate-to-severe ARDS who required mechanical ventilation therapy longer than 24 hours were randomly selected April 2017 to April 2019.The lung recruitment maneuver(RM)protocol was performed according to the patient's condition,their MP,lung ultrasound score(LUS),oxygenation index(P/F),and dead volume ratio(Vd/Vt),which were monitored before the RM and one hour after the RM.The patients were divided into the lung recruitment maneuver potential positive group(RMP-P group)and lung recruitment maneuver potential negative group(RMP-N group)according to whether the variation in the patient's RM aeration score(ΔLUS)was≥5.Differences in MP between the two groups were compared and correlations between MP variation(ΔMP),aeration score variation(ΔLUS),oxygenation index variation(ΔP/F),and dead volume ratio variation(ΔVd/Vt)were analyzed.The receiver operating characteristic curve(ROC)was used to calculate the predictive value of MP for the potential of RM and the prognosis(28-day mortality)of patients with moderate or severe ARDS.Results Eighty-three patients were enrolled in the study,45 in the RMP-P group and 38 in the RMP-N group.There was no statistical difference in the baseline levels between the two groups(P>0.05).After RM treatment,MP,LUS scores,and Vd/Vt for each patient in the two groups decreased significantly compared to the pre-RM values,whereas,the P/F increased significantly(P<0.05).The MP,LUS scores,and Vd/Vt in the RMP-P group were significantly lower than those in the RMP-N group(P<0.05),whereas there was no difference in the P/F between the two groups after RM treatment(P>0.05).TheΔMP,ΔLUS,andΔVd/Vt in the RMP-P group were significantly higher than those in the RMP-N group(P<0.05).There was no difference in theΔP/F between the two groups(P>0.05).There was a significant positive
作者
谢永鹏
刘克喜
王言理
刘素霞
郑慧
曹立娟
李小民
Xie Yongpeng;Liu Kexi;Wang Yanli;Liu Suxia;Zheng Hui;Cao Lijuan;Li Xiaomin(Department of Critical Care Medicine,Hospital of Lianyungang Affiliated to Xuzhou Medical University,Lianyungang 222000,China;Department of Emergency Medicine,Hospital of Lianyungang Affiliated to Xuzhou Medical University,Lianyungang 222000,China)
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2019年第12期1533-1538,共6页
Chinese Journal of Emergency Medicine
基金
江苏省连云港市科技计划资助项目(SH1601)。
关键词
急性呼吸窘迫综合征
机械功
肺复张潜能
肺部超声评分
预后
Acute respiratory distress syndrome
Mechanical power
Recruitment maneuver potential
Lung ultrasound score
Prognosis
