摘要
目的:基于中医传承平台软件分析1990年1月-2017年11月中国生物医学文献服务系统(SinoMed)、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库、万方数据知识服务平台的相关文献中关于中医药治疗溃疡性结肠炎湿热内蕴证的组方用药规律。方法:系统检索数据库中中医药治疗溃疡性结肠炎的文献后,录入中医传承辅助平台系统数据库中,运用数据分析技术,分析中医药治疗溃疡性结肠炎湿热内蕴证的组方用药规律。结果:共筛选出相关文献55篇,涉及94味中药,药性以寒性为主,其次是温性、平性、凉性;药味以苦味药最多,其次为甘、辛、酸;主要入胃、脾、大肠经;药物频次最多的10味药是黄连、白头翁、木香、黄苓、甘草;药物配伍前五位分别为黄苓-黄连、黄连-白头翁、黄连-木香、秦皮-白头翁、黄连-甘草,挖掘出核心药物组合15个,基于熵聚类关联分析得到3个新方。结论:利用中医传承辅助系统分析并阐明治疗溃疡性结肠炎湿热内蕴证的组方用药规律,初步揭示了湿热内蕴证的治疗原则为清热燥湿,同时辅以理气活血、健脾益气等药物,为中医临床治疗该病提供参考。
Objective:To analyze the regularity of prescription and medication in Chinese medicine for ulcerative colitis with the damp-heat accumulation syndrome in journal articles from SinoMed,China national knowledge infrastructure(CNKI),Chinese sci-tech periodical full-text database and Wanfang data knowledge service platform based on the Chinese medicine inheritance platform from January in 1990 to November in 2017.Methods:After systematically searching the literatures on Chinese medicine treatment for ulcerative colitis in these databases,recorded them into the system database of Chinese medicine inheritance auxiliary platform and analyzed the regularity of prescription and medication in Chinese medicine for ulcerative colitis with the damp-heat accumulation syndrome by data analysis technology.Results:Totally 55 related literatures were selected,involving 94 Chinese herbal medicines.The medicinal properties were mainly cold,followed by warm,neutral and cool;in terms of the medicinal flavor,most of them were bitter medicines,and then followed by sweet,spicy and sour;they were mainly found in the stomach,spleen and large intestine meridians;the ten most frequently used drugs were Coptis Chinensis(Huanglian),Radix Pulsatillae(Baitouweng),Radix Vladimiriae(Muxiang),Radix Scutellaria(Huangqin)and Radix et Rhizoma Glycyrrhizae(Gancao);the top five drug compatibility were respectively"Radix Scutellaria-Coptis Chinensis","Coptis Chinensis-Radix Pulsatillae","Coptis Chinensis-Radix Vladimiriae","Cortex Fraxini(Qinpi)-Radix Pulsatillae","Coptis Chinensis-Radix et Rhizoma Glycyrrhizae".15 core drug combinations were excavated,and 3 new prescriptions were obtained based on the correlation analysis of entropy clustering.Conclusion:By applying Chinese medicine inheritance auxiliary system to analyze and clarify the regularity of prescription and medication for ulcerative colitis with the damp-heat accumulation syndrome,it is preliminarily revealed that the treatment principle for the damp-heat accumulation syndrome is to clear hea
作者
谢亚娟
李鹤
朱亚珍
厉启芳
齐硕
李凯
孙冰
郑桂芝
于斌
XIE Yajuan;LI He;ZHU Yazhen;LI Qifang;QI Shuo;LI Kai;SUN Bing;ZHENG Guizhi;YU Bin
出处
《新中医》
CAS
2019年第12期13-16,共4页
New Chinese Medicine
基金
国家自然科学基金项目（81603509）
国家大学生创新创业训练项目（201810443025,201510443015）
山东省自然科学基金项目（ZR2014HQ051,ZR2016HM65）
山东省中医药科技发展项目（2015-241）
关键词
溃疡性结肠炎
中医药治疗
用药规律
组方规律
Ulcerative colitis
Chinese medicine treatment
Regularity of medication
Regularity of prescription
