摘要
目的瞬时受体电位香草酸亚型1(TRPV1)表达于许多代谢活性组织细胞中,参与糖代谢稳态维持的生理过程。阻断神经元上TRPV1通道可打破由神经肽P物质和降钙素基因相关肽引发的神经源性炎症,有益于2型糖尿病及其并发症炎性反应的改善作用;非神经元上TRPV1通道激活通过调节胃肠道激素、改善肠道菌群结构、提高胰岛素敏感性等参与糖稳态维持的调节,对2型糖尿病防治有益。本文就神经元与非神经元上的TRPV1通道与2型糖尿病的关系进行综述,为2型糖尿病防治提供潜在的靶点。
Transient receptor potential channel vanilloid type-1(TRPV1)is expressed in cells of many metabolically active tissues and is involved in maintaining glucose metabolism homeostasis.Blocking the TRPV1 channel on neurons can break the neurogenic inflammation caused by neuropeptide substance P and calcitonin gene-related peptide,which is beneficial to the improvement of type 2 diabetes and comorbidities.Activation of TRPV1 channel on non-neurons is involved in the regulation of glucose homeostasis by regulating gastrointestinal hormones,improving intestinal flora structure and improving insulin sensitivity,which is beneficial to the prevention and treatment of type 2 diabetes.This review summarized the relationship between the TRPV1 channel on neurons and non-neurons and T2D,providing a potential target for the prevention and treatment of T2D.
作者
蔡进
宋秀道
江国荣
CAI Jin;SONG Xiu-dao;JIANG Guo-rong(Clinical Pharmaceutical Laboratory of Traditional Chinese Medicine(TCM),Suzhou TCM Hospital Afiliated to Nanjing University of Chinese Medicine,Suzhou 215009,Jiangsu Province,China;Clinical Pharmaceutical Laboratory of Traditional Chinese Medicine,Suzhou Academy of Wumen Chinese Medicine,Suzhou 215009,Jiangsu Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2019年第23期3138-3141,共4页
The Chinese Journal of Clinical Pharmacology
基金
苏州市产业技术创新专项(民生科技-医疗卫生应用基础研究)资助项目(SYSD2016184)
苏州市科技发展计划课题资助项目(SYSD2017191)
关键词
瞬时受体电位香草酸亚型1
2型糖尿病
神经元
非神经元
糖稳态
transient receptor potential channel vanilloid type-1
type 2 diabetes
neurons
non-neurons
glucose metabolism homeostasis
