摘要
髓样细胞表达触发受体-2(triggering receptors expressed on myeloid cells-2,TREM-2)是新近发现的免疫球蛋白受体,对破骨的形成有重要作用。它通过与DAP12(DNAX activating protein of 12 k Da)形成复合体,接受信号,引起系列反应,参与破骨细胞的成熟和分化。本文对TREM-2/DAP12复合体的形成、作用及有关TREM-2的配体做一综述,以期为颌骨代谢的相关研究提供新思路。
TREM-2(triggering receptors expressed on myeloid cells-2)is a newly discovered immunoglobulin receptor,which plays an important role in osteoclast formation.It is involved in the maturation and differentiation of osteoclasts by forming complex with DAP12,receiving signals,causing a series of reactions.In this paper,the formation and function of TREM-2/DAP12 complex and the ligands related to TREM-2 are reviewed,in order to provide new ideas for the study of jaw metabolism.
作者
裴庆国
王佐林
PEI Qing-guo;WANG Zuo-lin(Department of Implantology,School and Hospital of Stomatology,Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai 20072,China)
出处
《口腔颌面外科杂志》
CAS
2019年第6期352-356,共5页
Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金面上项目(81670962)
科技部重点研发计划重点专项(2019-08-2023-07)
同济大学中央高校基本业务费专项基金(22120180196)
