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米非司酮联合自拟化瘀消■汤治疗未破裂型输卵管妊娠临床观察 被引量:3

Clinical Observation on Mifepristone Combined with Self-Made Huayu Xiaozheng Decoction in the Treatment of Unruptured Fallopian Tube Pregnancy
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摘要 目的探讨米非司酮联合自拟化瘀消汤治疗未破裂型输卵管妊娠的临床疗效。方法选取遵化市妇幼保健院2016年11月至2017年10月收治的未破裂型输卵管妊娠患者94例,按随机数字表法分为对照组和联合组,各47例。两组患者均肌肉注射甲氨蝶呤注射液,阴道止血,口服米非司酮片,联合组加用自拟化瘀消汤。结果联合组总有效率为95.74%,显著高于对照组的76.60%(P<0.05);与对照组比较,联合组患者治疗后的绒毛膜促性腺激素(β-HCG)水平复常时间,腹痛、阴道出血、妊娠包块消失时间均显著缩短(P<0.05);与治疗前比较,两组患者治疗后的β-HCG、孕酮(P)、卵泡刺激素(FSH)、糖类抗原125(CA125)水平均显著降低,且联合组显著低于对照组(P<0.05);联合组不良反应发生率为4.26%,显著低于对照组的21.28%(P<0.05)。结论米非司酮联合自拟化瘀消汤治疗未破裂型输卵管妊娠可明显降低激素及CA125水平。 Objective To investigate the clinical efficacy of mifepristone combined with self-made Huayu Xiaozheng Decoction in the treatment of unruptured tubal pregnancy.Methods Totally 94 patients with unruptured tubal pregnancy admitted to Zunhua Maternal and Child Health Care Hospital from November 2016 to October 2017 were selected and randomly divided into the control group and the combined group,47 cases in each group.The patients in the two groups were given intramuscular injection of Methotrexate Injection,vaginal hemostasis,and mifepristone,on this basis,the patients in the combined group were given self-made Huayu Xiaozheng Decoction.Results The total effective rate of the combined group was 95.74%,which was significantly higher than 76.60%of the control group(P<0.05).Compared with those in the control group,the recovery time ofβ-human chorionic gonadotropin(β-HCG)level,the disappearance time of abdominal pain,vaginal bleeding and pregnancy mass in the combined group were significantly shorter(P<0.05).Compared with those before treatment,the levels ofβ-HCG,progesterone(P),follicle stimulating hormone(FSH)and carbohydrate antigen 125(CA125)in the two groups were significantly lower,and those in the combined group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the combined group was 4.26%,which was significantly lower than 21.28%in the control group(P<0.05).Conclusion Mifepristone combined with self-made Huayu Xiaozheng Decoction is effective in the treatment of unruptured tubal pregnancy can significantly reduce the levels of hormone and CA125.
作者 户立生 许健 HU Lisheng;XU Jian(Zunhua Maternal and Child Health Care Hospital,Tangshan,Heibei,China 064200;Zunhua People's Hospital,Tangshan,Heibei,China 064200)
出处 《中国药业》 CAS 2019年第24期72-74,共3页 China Pharmaceuticals
基金 河北省医学科学研究重点项目[20181424]
关键词 米非司酮 化瘀消汤 未破裂型输卵管妊娠 激素水平 mifepristone Huayu Xiaozheng Decoction unruptured tubal pregnancy hormone level
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