摘要
目的 探讨糖基化终产物(AGE)及脂代谢紊乱与高原地区高血压的相关关系。方法 选取2018年1-11月该院健康体检人群中确诊原发性高血压(EH)患者207例(EH组),另选取年龄相匹配的血压正常人群329例(NT组),采用无创检测仪检测受试者皮肤组织中的AGE,并获取血脂等相关体检指标,比较两组AGE值和血脂等指标,分析EH发病的影响因素。结果 EH组的年龄、体质量指数(BMI)、AGE值、血清空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和肌酐水平高于NT组,差异均有统计学意义(P<0.05);EH组尿素氮稍高于NT组,高密度脂蛋白胆固醇(HDL-C)稍低于NT组,差异均无统计学意义(P>0.05)。多因素Logistic回归分析显示,AGE值、BMI、TG、LDL-C水平和年龄是EH发生的独立危险因素(P<0.05)。结论 皮肤组织中的AGE、BMI、TG、LDL-C和年龄是EH发生的高危因素。
Objective To explore the correlation of glycosylated end product(AGE)and lipid metabolism disorder to hypertension in plateau areas.Methods A total of 207 patients diagnosed with essential hypertension(EH)from January to November 2018 when underwent healthy check-up were selected(EH group),and other 329 age-matched subjects with normal blood pressure were served as the NT group.The AGE in skin tissues of all subjects was detected by using the noninvasive detector,and the blood lipids and other related physical examination indicators were obtained.The AGE values and indexes such as blood lipids were compared between the two groups,and the influence factors of the onset of EH were analysed.Results The age,body mass index(BMI),AGE value,serum fasting blood glucose(FPG),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and creatinine levels in the EH group were higher than those in the NT group,and the differences were statistically significant(P<0.05).The urea nitrogen in the EH group was slightly higher than that in the NT group,the high-density lipoprotein cholesterol(HDL-C)was slightly lower than that in the NT group,and no statistically significant difference was found between the two groups(P>0.05).Multivariate logistic regression analysis showed that AGE value,BMI,TG,LDL-C and age were independent risk factors for the onset of EH(P<0.05).Conclusion The AGE in skin tissues,BMI,TG,LDL-C and age are risk factors for the onset of EH.
作者
顾云帆
王春蓉
杨骥
陈芳
GU Yunfan;WANG Chunrong;YANG Ji;CHEN Fang(Cadre′s Physical Examination Center,the Second People′s Hospital of Yunnan Province,Kunming,Yunnan 650021,China)
出处
《重庆医学》
CAS
2019年第23期4071-4074,共4页
Chongqing medicine
关键词
高血压
糖基化终产物
高级
血脂
hypertension
glycosylated end products
advanced
blood lipids
