摘要
针对药物微粒制备、生物医用材料涂层等生物医学相关领域研究,本文根据模块化设计理念,将压电式微喷技术与机电工程及自动控制技术有机结合,设计了药物微喷射多功能系统,包括喷射支持子系统、XY运动平台、Z轴子系统以及快速安装子系统。然后,对整个药物微喷射多功能系统进行了运行调试,并通过阿莫西林微囊制备、钛合金载药涂层制备及球囊电极涂层制备等应用,验证了该系统的多功能性、合理性及可行性,表明该系统或可作为基础平台应用于生物医学工程、制药工程等多学科交叉技术的实验与研究。
For the researches relating to the biomedical fields such as preparation of drug micro-particulates and biomedical materials coating,according to the modular design concept and combing the piezoelectric micro-jetting technology with electromechanical engineering and automatic control technology,the drug micro-jetting multifunctional system was designed,which included the spraying support subsystem,X-Y motion platform,Z-axis subsystem and rapid installation subsystem.The drug micro-jetting multifunctional system was run and adjusted.The versatility,rationality and feasibility of this system were validated by the experiments of amoxicillin microcapsule preparation,titanium alloy drug-loaded coating preparation and balloon electrode coating preparation.It was shown that the system can be used as basic platform in multi-disciplinary cross technology research such as biomedical engineering,pharmaceutical engineering and so on.
作者
廖跃华
孙怀远
尧婉辰
金文涛
李晓欧
LIAO Yuehua;SUN Huaiyuan;YAO Wanchen;JIN Wentao;LI Xiaoou(Medical Instrument College,Shanghai University of Medicine and Health Sciences,Shanghai 201318,P.R.China;College of Medical Instrument and Food Engineering,University of ShangHai for Science and Technology,Shanghai 200093,P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2019年第6期1032-1037,共6页
Journal of Biomedical Engineering
基金
上海市生物医学工程学科建设项目（E1-2601-17-201002）
关键词
微喷射
多功能
系统结构
设计与测试
micro-jetting
multifunctional
system structure
design and testing
