摘要
滤泡辅助性T细胞(Tfh细胞)和滤泡调节性T细胞(Tfr细胞)是具有相反作用的CD4+T细胞亚群。Tfh细胞和Tfr细胞的免疫平衡对促进生发中心的正常形成、B细胞的适当增殖分化以及抗体的合理产生具有重要意义。Tfh细胞的过度活化或Tfr细胞的活性失控会导致免疫耐受性的丧失、生发中心的形成障碍以及高水平自身抗体的异常,从而诱导病理损伤和异常的免疫应答,最终引发自身免疫性疾病。未来,Tfh细胞和Tfr细胞的免疫平衡可能成为自身免疫性疾病预防和治疗的新指标。
Follicular helper T cells(Tfh cells)and follicular regulatory T cells(Tfr cells)are two subsets of CD4+T cells with opposite functions.The immune balance of Tfh cells and Tfr cells is of great significance for promoting the normal formation of germinal centers,proper proliferation and differentiation of B cells,and rational production of antibodies.Excessive activation of Tfh cells or uncontrolled activity of Tfr cells will lead to loss of immune tolerance,disorder of germinal centers formation and abnormal high levels of autoantibodies,which will induce pathological damage,and abnormal immune response,and eventually autoimmune diseases.In the future,the immune balance of Tfh cells and Tfr cells may become a new indicator for the prevention and treatment of autoimmune diseases.
作者
李珂颖
郝振华
LI Keying;HAO Zhenhua(Sanquan College of Xinxiang Medical College,Xinxiang 453000,China)
出处
《医学综述》
2019年第23期4657-4661,共5页
Medical Recapitulate
