摘要
胰岛素样生长因子(IGF)与靶组织细胞表面IGF1受体(IGF1R)特异性结合后可调节细胞凋亡、增殖、衰老等生理过程,与机体生长发育、疾病发生、发展密切相关。IGF1与IGF1Rα结合后可引起IGF1Rβ亚基构象改变,进而活化受体酪氨酸激酶,启动下游磷脂酰肌醇3激酶通路和丝裂原活化蛋白激酶通路,参与痤疮、银屑病等皮肤病的发病。本文综述IGF1R信号通路在相关皮肤病发病机制中的研究进展。
After binding to the specific insulin-like growth factor 1 receptor(IGF1R)on the surface of target tissue cells,IGF can regulate physiological processes such as apoptosis,proliferation and senescence,which are closely related to growth and development of the body,and occurrence and development of diseases.The binding between IGF1 and IGF1Rα can cause conformational changes of the beta subunit of IGF1R,lead to activation of receptor tyrosine kinase,initiation of the downstream phosphatidylinositol 3-kinase pathway and mitogen-activated protein kinase pathway,and finally participate in the occurrence of acne,psoriasis and other skin diseases.This review summarizes research advances in the role of the IGF1R signaling pathway in the pathogenesis of related skin diseases.
作者
汤红燕
肖斌
杨桂兰
Tang Hongyan;Xiao Bin;Yang Guilan(Department of Dermatology,Lanzhou University Second Hospital,Lanzhou 730000,China;Department of Dermatology,Changshu No.5 People′s Hospital,Changshu 215500,Jiangsu,China;Department of Cosmetic Dermatology and Venereology,Shenzhen Hospital of Southern Medical University,Shenzhen 518000,China)
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2019年第12期934-936,共3页
Chinese Journal of Dermatology
基金
皮肤病学教育部重点实验室(复旦大学皮肤病研究所-华山医院)开放课题基金(HS2017-1-003)。
