摘要
目的:探讨油桐花不同溶剂提取物的抗炎镇痛效果,为进一步研究治疗烧烫伤药物提供实验依据。方法:设计用醋酸致小鼠产生扭体反应的镇痛实验和二甲苯致小鼠耳廓肿胀、棉球致肉芽肿形成及蛋清致小鼠足跖肿胀的抗炎实验,观察各组小鼠耳郭和足跖肿胀度及肉芽肿系数和抑制率。结果:(1)油桐花水提物和氯仿提取物具有较好的镇痛效果,镇痛率分别为57.02%和57.85%,与模型组相比,差异有统计学意义(P<0.05)。(2)油桐花不同溶剂提取物均有一定的抗炎作用,具体表现为:在二甲苯和蛋清诱发的急性炎症实验中,水提物和氯仿提取物效果明显,差异有统计学意义(P<0.05)。(3)在棉球致肉芽肿形成慢性炎症实验中,水提物效果最优,差异有统计学意义(P<0.05)。结论:油桐花具有抗炎镇痛作用,尤其是水提物抗炎镇痛作用明显。
Objective:To study the anti-inflammatory and analgesic activities of different polar extractives from the tung tree flowers,and to provide scientific foundation for further study of the burn and scald drugs.Methods: Acetic acid writhing method was used to study the analgesic effect on mice. Auricular swelling induced by dimethylbenzene,cotton-pellet-induced granuloma,and carrageen-induced pedal edema in the mice were observed for the evalutation of anti-inflammatory activites of the extractives from tung tree flowers.Results:(1)The water extract group and chloroform extract group had better analgesic effect,and the analgesic percentage was 57.02% and 57.85% in the analgesic experiment. Compared with the model group,the difference was statistically significant(P<0.05).(2)Tung tree flowers extracts have a certain anti-inflammatory effect.In the acute inflammation experiments induced by xylene and egg whites,the effect of water extract group and chloroform extract group is obvious,the difference was statistically significant(P<0.05).(3)In the experiment of chronic inflammation caused by granuloma,the effect of water extract group is the best,the difference is statistically significant(P<0.05). Conclusion:The tung tree flowers show significant anti-inflammatory and analgesic activities,especially its water extract.
作者
张世凤
王永萍
谭芸
陈晓兰
隋艳华
ZHANG Shifeng;WANG Yongping;TAN Yun;CHEN Xiaolan;SUI Yanhua(Guizhou University of Traditional Chinese Medicine,Guizhou 550025,China)
出处
《贵阳中医学院学报》
2019年第6期11-15,共5页
Journal of Guiyang University of Chinese Medicine
基金
贵州省科学技术基金项目,项目编号:黔科合J字[2014]2031
关键词
油桐花
烧烫伤
抗炎
镇痛
提取溶剂
Tung tree flower
Burn and scald
Anti-inflammation
Analgesia
Extraction solvent
