摘要
目的:观察来氟米特、激素及羟氯喹联合治疗重症狼疮性肾炎的效果。方法:选取2014年1月1日-2018年12月31日笔者所在医院收治的重症狼疮性肾炎患者120例,按照随机数字表法分为对照组、试验组,各60例。给予对照组羟氯喹及泼尼松治疗,试验组在对照组基础上,加用来氟米特进行治疗。同时使用低分子肝素给予两组抗凝治疗,两组疗程均为12周,比较两组治疗的总体有效率,以及治疗前后血清白蛋白(Alb)、24 h尿蛋白定量变化,并记录治疗过程中的不良反应。结果:经过治疗后,试验组的总体有效率为95.00%,对照组为78.33%;试验组Alb为(33.61±5.84)g/L,对照组为(28.86±5.41)g/L;试验组24 h尿蛋白定量为(3.11±1.14)g,对照组为(3.73±1.38)g;试验组不良反应发生率5.00%,对照组为15.00%;差异均有统计学意义(P<0.05)。结论:来氟米特、激素及羟氯喹联合治疗重症狼疮性肾炎,效果显著,对于临床症状的改善起促进作用,值得在临床上推广使用。
Objective:To observe the effect of Leflunomide,Hormone and Hydroxychloroquine in the treatment of severe lupus nephritis.Method:A total of 120 patients with severe lupus nephritis were selected from January 1,2014 to December 31,2018 in our hospital.They were divided into the control group and the experimental group according to random number table method,60 cases in each group.The control group was treated with Hydroxychloroquine and Prednisone.The experimental group was treated with Leflunomide on the basis of the control group.At the same time,Low Molecular Weight Heparin(LMWH)was used to treat two groups of patients with anticoagulation.The two groups were treated for 12 weeks.The total effective rate of the two groups was compared,and the quantitative changes of serum albumin(Alb)and 24-hour urinary protein before and after treatment were recorded,and the adverse reactions during the treatment were recorded.Result:After treatment,the total effective rate of the experimental group was 95.00%,and that of the control group was 78.33%.Alb in the experimental group was(33.61±5.84)g/L,while that in the control group was(28.86±5.41)g/L.The 24-hour urinary protein level in the experimental group was(3.11±1.14)g,while that in the control group was(3.73±1.38)g.The incidence of adverse reactions was 5.00%in the experimental group and 15.00%in the control group.The differences were statistically significant(P<0.05).Conclusion:The combination of Leflunomide,Hormone and Hydroxychloroquine is effective in the treatment of severe lupus nephritis.It can promote the improvement of clinical symptoms and is worth popularizing in clinic.
作者
刘玉
汤一榕
陈冰双
LIU Yu;TANG Yirong;CHEN Bingshuang(The 476th Hospital of the People’s Liberation Army,Fuzhou 350000,China)
出处
《中外医学研究》
2019年第32期36-38,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
来氟米特
重症狼疮性肾炎
羟氯喹
激素
联合治疗
Leflunomide
Severe lupus nephritis
Hydroxychloroquine
Hormones
Combination therapy
