摘要
目的探讨降钙素原(PCT)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)对急性胰腺炎(AP)的诊断价值。方法选择2016年1月至2018年12月固原市人民医院收治的AP患者150例作为AP组,其中轻型急性胰腺炎(MAP)患者90例,重型急性胰腺炎(SAP)患者60例。另选择固原市人民医院体检无明显异常的健康者100例作为对照组。检测各组血清PCT、IL-6、hs-CRP水平,对AP患者进行急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ)。并绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),分析血清PCT、IL-6、hs-CRP水平预测SAP病情的诊断价值。结果AP患者血清PCT、IL-6、hs-CRP水平均显著高于对照组,差异均有统计学意义(P<0.05);SAP患者血清PCT、IL-6、hs-CRP水平均显著高于MAP患者,差异均有统计学意义(P<0.05);Spearman相关性分析显示,AP患者入院当天血清PCT、IL-6、hs-CRP水平均与APACHEⅡ评分呈正相关(r=0.845、0.808、0.816,P<0.05);血清PCT、IL-6、hs-CRP水平预测SAP病情的AUC分别为0.848、0.860、0.835。结论检测血清PCT、IL-6、hs-CRP水平,有助于AP的早期诊断及预后评估。
Objective To explore the application value of procalcitonin(PCT),interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)in the diagnosis of acute pancreatitis(AP).Methods A total of150 AP patients admitted to the Guyuan Municipal People′s Hospital from January 2016 to December 2018 were selected,including 90 cases of mild AP(MAP)and 60 cases of severe AP(SAP).Other 100 healthy people with no obvious abnormalities in the hospital physical examination at the same period were selected as the control group.The levels of serum PCT,IL-6 and hs-CRP were measured in each group,and the acute physiology and chronic health evaluationⅡ (APACHEⅡ)score was performed on the AP patients.The receiver operating characteristic(ROC)curve was drawn and the area under the curve(AUC)was calculated to analyze the diagnostic value of levels of serum PCT,IL-6 and hs-CRP in predicting SAP condition.Results The levels of serum PCT,IL-6 and hs-CRP in the AP patients were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of serum PCT,IL-6 and hs-CRP in the SAP patients were significantly higher than those in the MAP patients,and the difference was statistically significant(P<0.05).The Spearman correlation analysis showed that levels of serum PCT,IL-6 and hs-CRP at admission in the AP patients were positively correlated with the APACHEⅡscore(r=0.845,0.808,0.816,P<0.05).The AUC values of serum PCT,IL-6 and hs-CRP levels in predicting SAP condition were 0.848,0.860 and 0.835 respectively.Conclusion The detection of serum PCT,IL-6 and hs-CRP levels may contribute to the early diagnosis and prognosis evaluation of AP.
作者
曹文延
杨东亮
厚胜利
CAO Wenyan;YANG Dongliang;HOU Shengli(Department of Clinical Laboratory,Guyuan People′s Hospital,Guyuan,Ningxia 756000,China;Guyuan Social Security Administration,Guyuan,Ningxia 756000,China)
出处
《检验医学与临床》
CAS
2019年第23期3441-3443,共3页
Laboratory Medicine and Clinic
