摘要
目的探讨单次高剂量与多次常规剂量静脉输注免疫丙种球蛋白(intravenous immunoglobulin,IVIG)治疗新生儿ABO溶血病的临床效果。方法选择本院2018年2月-2019年3月收治的新生儿ABO溶血病患儿90例进行研究,根据治疗方法不同分组,两组均接受常规治疗,A组45例给予单次高剂量静脉输注,B组45例给予多次常规剂量输注,对治疗效果进行观察。结果 A组患儿黄疸消退时间、住院时间分别为(3.14±1.06)d、(5.38±1.35)d,均较B组(4.27±1.19)d、(8.19±1.46)d短(P<0.05);治疗前,两组患儿总胆红素(total bilirubin,TBiL)、血红蛋白(hemoglobin,Hb)水平差异无统计学意义(P>0.05),A组患儿治疗72 h后的TBiL、Hb水平分别为(113.67±21.54)μmol/L、(152.81±24.37)g/L,与B组(140.85±26.72)μmol/L、(139.69±20.13)g/L比较,差异有统计学意义(P<0.05);两组患儿治疗前的新生儿行为神经测定(neonatal behavioral neurological assessment,NBNA)差异无统计学意义(P>0.05),A组患儿治疗72 h后的NBNA评分为(37.82±1.46)分,与B组(34.92±1.27)分比较差异有统计学意义(P<0.05)。结论单次高剂量静脉输注IVIG治疗新生儿ABO溶血病的效果优于多次常规剂量静脉输注IVIG,可缩短病程,促进病情康复。
Objective To investigate the clinical effect of single high dose and multiple conventional doses of intravenous infusion of immunoglobulin(IVIG) in the treatment of neonatal ABO hemolytic disease. Methods 90 children with neonatal ABO hemolytic disease from February 2018 to March 2019 were selected for study according to different treatment methods. Both groups received regular treatment. 45 patients in group A received a single high-dose intravenous infusion, and 45 patients in group B received multiple conventional infusions. The therapeutic effect was observed. Results The time of jaundice regression and hospitalization in group A were(3.14 ± 1.06) d and(5.38 ± 1.35) d, respectively, which were shorter than those in group B(4.27 ± 1.19) d and(8.19 ± 1.46) d(P<0.05). Before treatment, there was no significant difference in the levels of total bilirubin(TBiL) and hemoglobin(Hb) between the two groups(P>0.05). The levels of TBIL and Hb in group A were(113.67 ± 21.54) μmol/L,(152.81 ± 24.37) g/L, respectively, compared with those in group B(140.85 ± 26.72) μmol/L and(139.69 ± 20.13) g/L(P<0.05). There was no significant difference in neonatal behavioral neurological assessment(NBNA) between the two groups(P>0.05). The NBNA score of group A was(37.82 ± 1.46) points after 72 hours of treatment, which was statistically significant compared with that of group B(34.92 ± 1.27) points(P<0.05). Conclusion The effect of single high-dose intravenous IVIG in the treatment of neonatal ABO hemolytic disease is better than multiple conventional intravenous IVIG injection, which can shorten the course of disease and promote the recovery of the disease.
作者
姜淑萍
JIANG Shuping(Department of Neonatology,Qinhuangdao Maternal and Child Health Hospital,Qinhuangdao Hebei 066000,China)
出处
《中国卫生标准管理》
2019年第22期78-81,共4页
China Health Standard Management
