摘要
目的探讨草酸艾司西酞普兰对冠心病伴焦虑抑郁患者负性情绪及心功能的影响。方法选取2018-03-01至2019-01-01在内蒙古自治区人民医院心血管内科及内蒙古自治区精神卫生中心住院的冠心病伴焦虑抑郁患者180例,根据治疗方法分为对照组(n=100)和研究组(n=80),其中对照组患者脱落10例,研究组患者脱落7例。对照组患者给予常规药物治疗,研究组患者在对照组治疗基础上给予草酸艾司西酞普兰片治疗;两组患者均连续治疗3个月。比较两组患者入院时及治疗第1、2、3个月后的汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、N末端脑钠肽前体(NT-proBNP)、肌酸激酶同工酶(CK-MB)。结果(1)时间与方法在HAMA评分、HAMD评分上存在交互作用(P<0.05),时间、方法在HAMA评分、HAMD评分上的主效应显著(P<0.05)。研究组患者治疗第1、2、3个月后HAMA评分、HAMD评分低于对照组(P<0.05)。(2)时间与方法在NT-proBNP、CK-MB上存在交互作用(P<0.05);时间、方法在NT-proBNP、CK-MB上主效应显著(P<0.05)。研究组患者治疗第1、2、3个月后NT-proBNP、CK-MB低于对照组(P<0.05)。结论草酸艾司西酞普兰可有效缓解冠心病伴焦虑抑郁患者负性情绪、疾病严重程度,减轻患者心肌损伤。
Objective To investigate the impact of escitalopram oxalate on negative emotion and cardiac function in coronary heart disease patients complicated with anxiety and depression.Methods From 2018-03-01 to 2019-01-01,a total of 180 coronary heart disease inpatients complicated with anxiety and depression were selected in the Department of Cardiovascular Medicine,the People’s Hospital of Inner Mongolia Autonomous Region and Mental Health Center of Inner Mongolia Autonomous Region,and they were divided into control group(n=100)and study group(n=80)according to therapeutic methods,thereinto 10 cases were excluded in control group,7 cases were excluded in study group.Patients in control group were given conventional treatment,while patients in study group were given escitalopram oxalate based on that of control group;both groups were continuously drugs treated for 3 months.Comparison of HAMA score,HAMD score,NTproBNP and CK-MB was made between the two groups at admission,1 month,2 months and 3 months after treatment.Results(1)There was statistically significantly interaction in HAMA score and HAMD score between time and method(P<0.05);main effects of time and method were statistically significant in HAMA score and HAMD score(P<0.05).HAMA score and HAMD score in study group were statistically significantly lower than those in control group 1 month,2 months and 3 months after treatment(P<0.05).(2)There was statistically significantly interaction in NT-proBNP and CK-MB between time and method(P<0.05);main effects of time and method were statistically significant in NT-proBNP and CK-MB(P<0.05).NTproBNP and CK-MB in study group were statistically significantly lower than those in control group 1 month,2 months and 3 months after treatment(P<0.05).Conclusion Escitalopram oxalate can effectively relieve the negative emotion and severity of illness in coronary heart disease patients complicated with anxiety and depression,as well as reduce the myocardial damage.
作者
王启辉
陈丽霞
王思洋
曹雪
WANG Qihui;CHEN Lixia;WANG Siyang;CAO Xue(Mental Health Center of Inner Mongolia Autonomous Region,Hohhot 010010,China)
出处
《实用心脑肺血管病杂志》
2019年第11期85-88,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
内蒙古自治区科技计划项目（201602100)
关键词
冠心病
焦虑
抑郁
草酸艾司西酞普兰
“双心”治疗模式
心功能
Coronary disease
Anxiety
Depression
Escitalopram oxalate
Psycho-cardiology treatment mode
Cardiac function
