摘要
细胞分裂周期相关蛋白(cell division cycle-associated protein,CDCA)家族是细胞增殖的重要调控因子。越来越多的研究表明这类蛋白分子在肿瘤细胞中高表达,并具有调节肿瘤细胞生长周期、促进肿瘤细胞增殖和减少肿瘤细胞凋亡的作用,导致患者预后较差。本文就CDCA蛋白家族成员在肿瘤发生发展中的作用进行综述。
The cell division cycle-associated protein(CDCA)family are important regulators of cell proliferation.More and more studies have shown that these proteins are highly expressed in tumors and regulate the growth cycle of tumor cells,promote the proliferation and reduce the apoptosis,thus leading to poor prognosis of cancer patients.This article reviews the role of CDCA protein family in tumors.
作者
高鑫
张淑芳
GAO Xin;ZHANG Shufang(Central Laboratory,Affiliated Haikou Hospital of Xiangya Medical College,Central South University,Haikou 570208,Hainan Province,China;Clinical Laboratory,the First People's Hospital of Huaihua,Huaihua 418000,Hu'nan Province,China)
出处
《解放军医学院学报》
CAS
2019年第9期904-906,F0003,共4页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金资助项目(81460450
81760465)
2017年海南省创新团队资助项目(2017CXTD010)~~
关键词
细胞分裂周期相关蛋白
肿瘤
治疗靶点
生物标记物
cell division cycle-associated proteins
tumors
therapeutic targets
biomarkers
