摘要
目的观察氨甲环酸减少全髋关节置换围术期失血量的临床效果。方法选择医院骨一科行初次单侧全髋关节置换的患者62例为研究对象,随机分为观察组和对照组,每组31例。观察组在安置假体后予以氨甲环酸静脉滴注,对照组在安置假体后予以氯化钠静脉滴注。比较2组术后引流量、总失血量、隐性出血量及输血量;2组术后1、3、7 d血红蛋白、红细胞压积变化;并发症发生情况。结果观察组术后引流量、总出血量、隐性失血量和术后输血量均少于对照组(P <0. 01);术前,2组血红蛋白及红细胞压积比较差异无统计学意义(P> 0. 05),术后1、3、7 d观察组血红蛋白及红细胞压积均高于对照组(P <0. 01);2组术后并发症发生率比较差异无统计学意义(P> 0. 05)。结论全髋关节置换患者予以氨甲环酸静脉滴注可有效减少术后出血,降低红细胞压积、血红蛋白水平的波动,且具有较高的安全性。
Objective To observe the clinical effect of tranexamic acid in reducing perioperative blood loss during total hip arthroplasty. Methods Sixty-two patients with primary unilateral total hip arthroplasty were randomly divided into observation group and control group,with 31 cases in each group. The observation group was given an intravenous infusion of tranexamic acid after placement of the prosthesis,and the control group was given a sodium chloride pulse after the placement of the prosthesis. The postoperative drainage volume,total blood loss,recessive blood loss and blood transfusion volume were compared between the two groups. Hemoglobin,hematocrit changes and complications were compared between the 2 groups at1,3,and 7 days after operation. Results The postoperative drainage volume,total blood loss,recessive blood loss and postoperative blood transfusion were lower in the observation group than in the control group( P < 0. 01). There was no significant difference in hemoglobin and hematocrit between the two groups before operation( P > 0. 05). At 1,3,and 7 days after operation,hemoglobin and hematocrit in the observation group were higher than those in the control group( P < 0. 01). There was no significant difference in the incidence of postoperative complications between the two groups( P > 0. 05). Conclusion Intravenous infusion of tranexamic acid in patients with total hip arthroplasty can effectively reduce postoperative bleeding,reduce hematocrit and hemoglobin levels,and has high safety.
作者
吴小军
钱薇
WU Xiaojun;QIAN Wei(Department of Orthopaedics,Second People's Hospital of Yibin City,Sichuan Province,Yibin City 644000,China)
出处
《临床合理用药杂志》
2019年第29期13-15,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
氨甲环酸
全髋关节置换
失血量
Tranexamic acid
Total hip replacement
Blood loss
