摘要
目的:探究藏药多血康胶囊防治高原红细胞增多症(HAPC)的作用机制。方法:依据HAPC国际诊断标准纳入14例HAPC患者,患者服用多血康胶囊1个疗程,分别检测治疗前后的血常规、体征、核磁共振脑成像、血氧饱和度等相关指标。结果:HAPC患者治疗后紫癜、头晕、头痛、气喘、心悸、手脚心发热等症状均缓解(P<0.01),血氧饱和度(SpO2)和心率(PR)均升高(P<0.01),RBC、HGB、HCT均降低(P<0.05),总有效率92.9%。MRI结果显示:治疗后左侧颞叶CBV明显升高(P<0.05);右侧额叶、右侧颞叶、右侧枕叶MTT均明显降低(P<0.01或P<0.05)。结论:藏药多血康胶囊对HAPC确有治疗效果,可通过调节血常规(RBC、HGB、HCT)、SpO2和PR等治疗HAPC患者。MRI脑成像结果提示多血康胶囊防治HAPC可能与其服药时间长短有关。
Objective: To explore the mechanism of Tibetan medicine Duoxuekang capsule in preventing and treating high altitude polycythemia(HAPC). Methods: According to the international diagnostic criteria of HAPC,14 patients with HAPC were enrolled. The patients were tested for blood routine, physical signs, nuclear magnetic resonance brain imaging, blood oxygen saturation and other related indicators before and after taking one course of Duoxuekang Capsule capsules. Results: After treatment, symptoms of purpura, dizziness, headache,asthma, palpitations, and hands and feet fever were relieved(P<0.01), blood oxygen saturation(SpO2) and heart rate(PR) were increased(P<0.01). The RBC, HGB and HCT was decreased(P<0.05), and the total effective rate was 92.9%. Conclusion: Tibetan medicine Duoxuekang capsule has a therapeutic effect on HAPC. It can treat HAPC patients by regulating blood routine(RBC, HGB, HCT), SpO2 and PR. The results of MRI brain imaging suggest that the prevention and treatment of HAPC by Duoxuekang capsule may be related to the duration of its administration.
作者
尕藏措
三智加
公保东智
周泽加
洛桑东智
周则
更藏加
GA Zang-cuo;SAN Zhi-jia;GONGBAO Dong-zhi;ZHOU Ze-jia;LUOSANG Dong-zhi;ZHOU Ze;GENG Zang-jia(Qinghai Tibetan Hospital,XiPing Qinghai 810007,China;Qinghai University,Xi'ning Qinghai 810016,China;Tibetan Hospital of Zeku County,Zeku Qinghai 811499.China;Southwest University for Nationalities,Chengdu Sichuan 610041,China)
出处
《中医药导报》
2019年第20期44-47,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点研发计划项目(2017YFC1703901,2017YFC1703902)
关键词
多血康胶囊
高原红细胞增多症
MRI
作用机制
Duoxuekang capsule
high altitude polycythemia(HAPC)
MRI
the mechanism of action
