摘要
目的 分析原发性输尿管尿路上皮癌患者手术后长期生存情况及预后相关因素.方法 回顾性分析2010年1月至2013年12月于安徽医科大学第二附属医院行手术治疗的原发性输尿管尿路上皮癌患者的临床病理及随访资料,采用Kaplan-Meier法计算生存率,Cox回归法分析各相关因素对预后的影响.结果 共72例输尿管尿路上皮癌患者纳入研究,其中男性49例,女性23例,平均66. 7岁,随访13~102个月,平均随访时间41. 4个月. 72例患者中,46例死亡,3年生存率为61. 1% ,5年生存率为40. 3% ,中位生存时间为40个月.单因素分析结果显示:年龄、性别、肿瘤部位、大小、是否合并肾积水、高血压、糖尿病等与原发性输尿管尿路上皮癌患者的预后无明显相关性(P>0. 05),多因素分析结果显示:肿瘤分级及临床分期是影响此类患者预后的独立因素(P<0. 05).结论 原发性输尿管尿路上皮癌患者中,肿瘤级别和临床分期越高,预后越差.
Objective To evaluate the prognostic factors and outcomes of patients with primary urothelial carcinoma of the ureter.Methods A retrospective study was conducted on 72 patients diagnosed with primary urothelial carcinoma of the ureter in our hospital and received surgical treatment from January 2010 to December 2013.The effects of relative prognostic factors collected from clinicopathologic data were analyzed by Kaplan-Meier and Cox regression analysis.Results A total of 72 patients were enrolled in this study,including 49(68%)male patients and 23(32%)female patients,in which the mean age was 66.7 years.The mean follow-up time was 41.4(range from 13-102)months.Among them,46 patients were died during the follow-up.The three and five-year overall survival rates were 61.1%and 40.3%respectively,with a median survival time of 40 months.Univariate analysis showed that age,gender,tumor side,tumor size,hydronephrosis,hypertension and diabetes were not significantly associated with the prognosis of the patients.Cox multivariate analysis indicated that tumor grade and clinical stage were independent risk factors.Conclusions In patients with primary urothelial carcinoma of the ureter,the advanced tumor grade and clinical stage were related to a poor prognosis.
作者
方露
张涛
王毅
毕良宽
谢栋栋
于德新
Fang Lu;Zhang Tao;Wang Yi;Bi Liangkuan;Xie Dongdong;Yu Dexin(Department of Urology,the Second Hospital of Anhui Medical University,Hefei 230601,China)
出处
《国际泌尿系统杂志》
2019年第6期1004-1008,共5页
International Journal of Urology and Nephrology
关键词
泌尿系肿瘤
无病生存
预后
Urologic Neoplasms
Disease-Free Survival
Prognosis
