摘要
MicroRNA(miRNA)是一类高度保守的非编码调控的小分子单链RNA,控制多种人类必需基因的表达,参与各种信号通路,并在一些生物体内发挥重要的生物学作用。MiR-34作为特异性miRNA,在人类多种癌症中表达失调,与肿瘤抑制因子p53具有协同作用,在抑制肿瘤发生发展中起重要作用。近年来,miR-34在肿瘤中的作用日益受到关注,有望成为肿瘤治疗的新靶点。
MicroRNA(miRNA)is a highly conserved single-stranded small non-coding RNA which controls the expression of many essential human genes,participates in a variety of signaling pathways,and plays an important biological role in some organisms.MiR-34,as a specific miRNA,is dysregulated in a variety of human cancers.Because of its synergistic effect with tumor suppressor p53,miR-34 plays an important role in inhibiting tumorigenesis and development.In recent years,the role of miR-34 in tumor has been paid more and more attention,and it is expected to become a new target of tumor therapy.
作者
朱泽民
徐涛
唐才喜
ZHU Zemin;XU Tao;TANG Caixi(Department of Hepatobiliary and Pancreatosplenic Surgery,Affiliated Zhuzhou Hospital,Xiangya Medical College,Central South University,Zhuzhou Hunan 412007,China)
出处
《临床与病理杂志》
2019年第11期2525-2531,共7页
Journal of Clinical and Pathological Research
基金
湖南省科技计划项目(2016SK4006)
湖南省医药卫生科研计划项目(c2016109)~~
