摘要
目的分析半夏白术天麻汤治疗原发性高血压风痰上扰证的有效性及安全性,找到更为有效且安全的高血压治疗手段,以指导临床。方法选取江阴市中医院2017年12月至2018年9月收治的200例原发性高血压患者,根据随机数表法分为对照组与治疗组,各100例。对照组单一口服厄贝沙坦片治疗,治疗组在口服厄贝沙坦片的基础上加用半夏白术天麻汤。对比两组治疗4周后证候积分变化情况、血压水平改善情况、炎症指标[超敏C反应蛋白(Hypersensitive C reactive protein,hs-CRP)、白细胞介素-6(Interleukin-6,IL-6)、单核细胞趋化蛋白-1(Monocyte chemotactic protein-1,MCP-1)]、血脂指标[总胆固醇(Total Cholesterol,TC)、三酰甘油(Triglyceride,TG)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)、高密度脂蛋白胆固醇(High-density Lipoprotein Cholesterol,HDL-C)]、生活质量改善情况、疗效及安全性。结果治疗组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后各时点,患者证候积分均较治疗前明显降低,且治疗组降低幅度较对照组显著,差异有统计学意义(P<0.05);治疗4周后,两组hs-CRP、IL-6、MCP-1水平与治疗前降低幅度比较,差异有统计学意义(P<0.05),两组TC、TG、LDL-C水平与治疗前降低幅度比较,差异有统计学意义(P<0.05),两组HDL-C水平与治疗前升高幅度比较,差异有统计学意义(P<0.05),生活质量较治疗前改善情况优于对照组,差异有统计学意义(P<0.05);治疗期间,两组患者均未发生明显不良反应,且各项常规检查均正常。结论半夏白术天麻汤治疗原发性高血压疗效确切,患者各临床症状更好更快缓解,机体炎症反应减轻,血压及血脂水平明显改善,生活质量显著提升,且短期内无明显不良反应发生,短期内安全性理想。
Objective To analyze the effectiveness and safety of Banxia Baizhu Tianma Decoction in the treatment of primary hypertension with syndrome of wind-phlegm invading upward,to find more effective and safer treatment for hypertension,and to provide the guidance for the clinic.Methods 200 patients with primary hypertension admitted in the Jiangyin Hospital of Traditional Chinese Medicine from December 2017 to September 2018 were selected and divided into the control group and the treatment group,with 100 cases in each group.The control group was given oral irbesartan tablets,while the treatment group was given Banxia Baizhu Tianma Decoction based on the treatment of the control group.After treatment for 4 weeks,the changes of syndrome score,improvement of blood pressure,inflammatory factors[hypersensitive C reactive protein(hs-CRP),interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1)],blood lipid indexes[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],improvement of quality of life,efficacy and safety were compared between the two groups.Results The total effective rate of treatment group was higher than that of control group with significance(P<0.05);at all the time points after the treatment,symptom score decreased significantly than that before treatment,and the decreased range in the treatment group was significantly larger than that of the control group,with significance(P<0.05).After treatment for 4 weeks,compared with those before treatment,there were differences in the decreased range of hs-CRP,IL-6,MCP-1 between the two groups with significance(P<0.05).Compared with those before treatment,there were differences in the decreased range of TC,TG,LDL-C in both groups with significance(P<0.05).Compared with those before treatment,there was difference in the increasing range of HDL-C in both groups with significance(P<0.05).The improvement of quality of life in the treatment group was better than that in the control group(P<0.05);Th
作者
马惠倪
苏伟
夏晶晶
沈烨
MA Hui-ni;SU Wei;XIA Jing-jing;SHEN Ye(Nanjing University of Chinese Medicine,Nanjing Jiangsu 210000;Jiangyin Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangyin Jiangsu 214443;Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine(Wuxi Chinese Medicine Hospital),Wuxi Jiangsu 214000)
出处
《世界中西医结合杂志》
2019年第11期1579-1583,共5页
World Journal of Integrated Traditional and Western Medicine
基金
江苏省中管局基金项目(JD201526)
关键词
原发性高血压
风痰上扰证
半夏白术天麻汤
安全性
Primary hypertension
Syndrome of wind-phlegm invading upward
Banxia Baizhu Tianma Decoction
Safety
