摘要
目的探讨实验室指标在不完全型川崎病(KD)冠状动脉损伤诊断及预后中的临床价值。方法收集湖南省人民医院儿科2014年1月-2016年12月295例KD住院患儿的临床资料,295例KD患儿中有86例(29.2%)不完全型KD患儿,对其实验室指标检测结果进行比较、分析,并随访1年。结果86例不完全型KD患儿中28例发生冠状动脉损伤。冠状动脉损伤组C反应蛋白(CRP)、D-二聚体(DD)水平高于非冠状动脉损伤组(P<0.01)。多因素Logistic回归分析结果显示,CRP和DD均是冠状动脉损伤的独立危险因素(P<0.05),但与冠状动脉损伤预后无关(P>0.05)。CRP检测、DD检测和CRP+DD联合检测诊断冠状动脉损伤的受试者工作特征(ROC)曲线的曲线下面积(AUC)分别为0.965、0.759、0.989。结论CRP和DD可作为不完全型KD患儿冠状动脉损伤的诊断和鉴别诊断标志物。
Objective To investigate the role of laboratory parameters in the diagnosis and prognosis of incomplete Kawasaki disease(KD)with coronary artery lesions.Methods The clinical data of 295 patients with KD in Hunan Provincial People's Hospital from January 2014 to December 2016 were collected and analyzed retrospectively,and the laboratory parameter results of 86(29.2%)patients with incomplete KD were compared and analyzed.The investigated patients were followed up for 1 year.Results A total of 28 of 86 patients with incomplete KD had coronary artery lesions.The levels of C-reactive protein(CRP)and D-dimer(DD)in patients with coronary artery lesions were higher than those without coronary artery lesions(P<0.01).Multivariate Logistic regression analysis showed that CRP and DD were independent risk factors for coronary artery lesions(P<0.05).The levels of CRP and DD were not related to the prognosis of coronary artery lesions(P>0.05).The areas under receiver operating characteristic(ROC)curves(AUC)of CRP and DD determinations were 0.965 and 0.759,respectively,and the AUC of the combination determination of CRP and DD were 0.989.Conclusions CRP and DD can be used as the markers for the diagnosis and differential diagnosis of coronary artery lesions in incomplete KD.
作者
陈杰
周玉杰
赵梦华
袁勇华
谭超超
曹友德
CHEN Jie;ZHOU Yujie;ZHAO Menghua;YUAN Yonghua;TAN Chaochao;CAO Youde(Department of Clinical Laboratory,the First Affiliated Hospital of Hunan Normal University,Hunan Provincial People's Hospital,Changsha 410005,Hunan,China;Department of Pediatrics,the First Affiliated Hospital of Hunan Normal University,Hunan Provincial People's Hospital,Changsha 410005,Hunan,China)
出处
《检验医学》
CAS
2019年第11期998-1001,共4页
Laboratory Medicine
基金
湖南省自然科学基金(2017JJ2151)
