摘要
目的:探讨EpCAM在非小细胞肺癌中表达及其与非小细胞肺癌转移预后关系。方法:选取2011年2月-2013年2月在我院经病理确诊并手术切除的非小细胞肺癌患者作为研究对象,免疫组化法检测肿瘤组织、癌旁组织和正常肺组织EpCAM表达,对患者进行随访,观察EpCAM表达与患者术后转移和生存的相关性。结果:肺癌组织EpCAM表达阳性率高于正常组织和癌旁组织,差异有统计学意义(P<0.05)。EpCAM阴性患者生存率和中位生存时间均高于阳性患者,差异均有统计学意义(P<0.05)。EpCAM阴性患者5年内淋巴结转移和远处转移率均低于EpCAM阳性患者,差异均有统计学意义(P<0.05)。结论:EpCAM在非小细胞肺癌中高表达,且与Ⅰ期非小细胞肺癌患者术后远期转移和生存相关,干扰EpCAM功能可能是非小细胞肺癌的新治疗靶点。
Objective:To investigate the expression of EpCAM in non-small cell lung cancer and its relationship with metastasis and prognosis of non-small cell lung cancer.Methods:The patients with non-small cell lung cancer who were confirmed by pathology and surgically resected in our hospital from February 2011 to February 2013 were selected as the research subjects.The immunohistochemical method was used to detect the expression of EpCAM in tumor tissues, adjacent tissues and normal lung tissues. The patients were followed up to observe the correlation between EpCAM expression and postoperative metastasis and survival.Results:The positive rate of EpCAM expression in lung cancer tissues was higher than that in normal tissues and adjacent tissues, and the difference was statistically significant(P<0.05).The survival rate and median survival time of EpCAM negative patients were all higher than those of positive patients, and the difference was statistically significant(P<0.05).The lymph node metastasis and distant metastasis rate of EpCAM negative patients were all lower than those of EpCAM positive patients in 5 years, and the difference was statistically significant(P<0.05).Conclusion:The EpCAM is highly expressed in non-small cell lung cancer, is associated with long-term metastasis and survival in patients with stage I non-small cell lung cancer, and interfering with EpCAM function may be a new therapeutic target for non-small cell lung cancer.
作者
吴海乔
邵威
胡君程
杨冰洪
WU Haiqiao;SHAO Wei;HU Juncheng(Department of Pathology,the 174th Hospital of PLA,Xiamen City,Fujian Province 361003)
出处
《医学理论与实践》
2019年第22期3596-3598,共3页
The Journal of Medical Theory and Practice
关键词
非小细胞肺癌
上皮细胞黏附分子
转移
预后
Non small cell lung cancer
Epithelial cell adhesion molecule
Metastasis
Prognosis
