摘要
目的探讨盐酸戊乙奎醚对降低宫缩乏力剖宫产产妇卡前列素氨丁三醇注射液不良反应的作用。方法对我院产科2017年1月至2019年1月收治的120例宫缩乏力剖宫产产妇开展前瞻性研究,按照随机数字表法随机将其分为对照组(60例,卡前列素氨丁三醇+安慰剂)和观察组(60例,卡前列素氨丁三醇+盐酸戊乙奎醚)。比较两组的生命体征、不良反应发生情况、产程时间、产后出血情况、新生儿Apgar评分。结果两组给药前、后的平均动脉压、心率均无明显变化(P>0.05)。观察组的恶心、呕吐、胸闷不良反应发生率均明显低于对照组(P<0.05)。观察组的第一产程时间、总产程时间均明显短于对照组(P<0.05)。观察组的产后2 h出血量、产后24 h出血量均明显少于对照组,产后出血率明显低于对照组(P<0.05)。新生儿娩出1 min、5 min时,观察组的Apgar评分均明显高于对照组(P<0.05)。结论盐酸戊乙奎醚用于宫缩乏力产妇剖宫产术中,可有效减少因卡前列素氨丁三醇引起的不良反应,加快产程进展,减少产后出血情况,降低新生儿窒息风险。
Objective To investigate the effect of penehyclidine hydrochloride on reducing the adverse reactions of carboprost tromethamine injection in cesarean section puerperae with uterine atony. Methods A prospective study was carried out on 120 cases of cesarean section puerperae with uterine atony who were admitted in obstetrics department of our hospital from January 2017 to January 2019. According to the random number table method, the puerperae were randomly divided into control group(60 cases, carboprost tromethamine+placebo) and observation group(60 cases, carboprost tromethamine+penehyclidine hydrochloride). The vital signs, adverse reactions, time of labor, postpartum hemorrhage and newborn Apgar score were compared between the two groups. Results There were no significant changes in mean arterial pressure and heart rate before and after administration in the two groups(P>0.05). The incidence of adverse reactions of nausea, vomiting, chest distress in the observation group were significantly lower than those in the control group(P<0.05). The times of first stage of labor and the total stage of labor in the observation group were significantly shorter than those in the control group(P<0.05).The amount of postpartum hemorrhage at 2 hours and 24 hours in the observation group were significantly less than those in the control group, and the rate of postpartum hemorrhage was significantly lower than that in the control group(P <0.05).When the newborn delivered for 1 min and 5 min, the newborn Apgar score in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Penehyclidine hydrochloride used in cesarean section pnerperae with uterine atony can effectively reduce the adverse reactions caused by carboprost tromethamine, accelerate the progress of labor, reduce postpartum hemorrhage and the risk of neonatal asphyxia.
作者
马延平
MA Yan-ping(Maternal and Child Health Hospital In Lintong,Xi'an 710600,China)
出处
《临床医学研究与实践》
2019年第34期161-163,共3页
Clinical Research and Practice
关键词
剖宫产
宫缩乏力
卡前列素氨丁三醇
盐酸戊乙奎醚
产后出血
cesarean section
uterine atony
carboprost tromethamine injection
penehyclidine hydrochloride
postpartum hemorrhage
