摘要
目的评价瑞舒伐他汀抗动脉粥样硬化的临床价值。方法纳入2017年2月至2018年2月收治的动脉粥样硬化患者84例,以随机数字分组法分为对照组和观察组,各42例。对照组给予阿司匹林肠溶片,观察组给予瑞舒伐他汀钙片。比较两组治疗效果。结果观察组、对照组的治疗总有效率分别为95.24%、73.81%,观察组显著高于对照组,差异具有统计学意义(P<0.05)。观察组、对照组用药不良反应总发生率分别为7.14%、23.81%,观察组显著低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者血清TC、IL-6、LDL-C水平比较,差异无统计学意义(P>0.05);治疗后,两组患者血清TC、IL-6、LDL-C水平均明显下降,且观察组低于对照组,差异具有统计学意义(P<0.05)。结论瑞舒伐他汀抗动脉粥样硬化的临床价值显著,用药不良反应少,值得临床应用。
Objective To evaluate the clinical value of rosuvastatin again st atherosclerosis. Methods From February2017 to February 2018, 84 atherosclerotic patients were enrolled and divided into control group and observation group by random number grouping method, with 42 cases in each group. The control group was given aspirin enteric coated tablets,and the observation group was given rosuvastatin calcium tablets. The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group and the control group was 95.24% and 73.81%respectively, which of the observation group was significantly higher than the control group, the difference was statistically significant(P<0.05). The total incidence of adverse reactions in the observation group and the control group was 7.14% and23.81% respectively, which of the observation group was significantly lower than the control group, the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the levels of serum TC, IL-6 and LDL-C between the two groups(P >0.05);after treatment, the levels of serum TC, IL-6 and LDL-C in the two groups decreased significantly, and those in the observation group were lower than the control group, the differences were statistically significant(P<0.05). Conclusion The resuvarastatin against atherosclerosis has significant clinical value and less adverse reactions, which is worthy of clinical application.
作者
石海刚
SHI Hai-gang(No.1 Ward of Neurology Department,the People's Hospital of Pingyu County,Zhumadian 463400,China)
出处
《临床医学研究与实践》
2019年第34期61-62,共2页
Clinical Research and Practice
