摘要
目的分析氯沙坦对冠心病行经皮冠状动脉介入术(PCI)患者肾功能的保护效果。方法选取2016年1月至2018年1月在本院行PCI治疗的88例患者,采用随机数字表法将其分为对照组与观察组,各44例。两组患者PCI术中均使用对比剂,对照组给予安慰剂,观察组给予氯沙坦。比较两组患者的肾功能及保护效果。结果两组患者的对比剂使用量比较,差异无统计学意义(P>0.05);术后2 d,观察组患者的Scr、SUA、BUN水平均低于对照组,eGFR、肾素活性、醛固酮及AngⅡ水平均高于对照组(P<0.05)。结论氯沙坦可减少对比剂对于肾素活性的抑制作用,保护患者肾功能,临床应用价值较高。
Objective To analyze the protective effect of losartan on renal function in patients with coronary heart disease undergoing percutaneous coronary intervention(PCI). Methods From January 2016 to January 2018, 88 patients who underwent PCI treatment in our hospital were selected and divided into control group and observation group by random number table method, with 44 cases in each group. The patients in both groups were given contrast agent during PCI, and the control group was given placebo, the observation group was given losartan. The renal function and protective effects were compared between the two groups. Results The dosage of contrast agent between the two groups was not significantly different(P>0.05). At 2 day after operation, the levels of Scr, SUA and BUN in the observation group were lower than those in the control group, and the eGFR, renin activity, aldosterone and Ang Ⅱ levels in the observation group were higher than those in the control group(P<0.05). Conclusion Losartan can reduce the inhibitory effect of contrast agent on renin activity,protect renal function, and has higher clinical application value.
作者
韩会香
HAN Hui-xiang(Cardiology Department,Traditional Chinese Medicine Hospital of Puyang,Puyang 457000,China)
出处
《临床医学研究与实践》
2019年第34期46-47,共2页
Clinical Research and Practice
关键词
经皮冠状动脉介入术
氯沙坦
肾功能
percutaneous coronary intervention
losartan
renal function
