摘要
目的探讨慢性阻塞性肺疾病(COPD)A、E、M型双气相配准CT定量参数差异及其与肺功能的相关性。资料与方法对87例COPD患者行双气相CT扫描,定量测量低密度衰减区域百分比(%LAA-950insp、%LAA-856exp)、肺气肿区域百分比(Emph%)及支气管壁厚度,进行A、E、M分型。比较CT定量参数(%LAA-950insp、%LAA-856exp、Emph%)和肺功能[FEV1%、FEV1/FVC、一氧化碳扩散量(DLCO)、残气量与肺总量的比值(RV/TLC)],分析CT定量参数与肺功能的相关性。结果 3型COPD患者CT定量参数和肺功能的差异均有统计学意义(P<0.05)。%LAA-950insp、%LAA-856exp、Emph%及RV/TLC的大小排序均为A型<E型<M型;FEV1%、FEV1/FVC、DLCO的大小排序均为A型>E型>M型。A型%LAA-950insp和Emph%与肺功能均无相关性(P>0.05);%LAA-856exp与肺功能FEV1%、FEV1/FVC、DLCO均呈负相关,与RV/TLC呈正相关(P<0.05);E型和M型%LAA-950insp、%LAA-856exp、Emph%与FEV1%、FEV1/FVC、DLCO均呈负相关,与RV/TLC呈正相关(P<0.05)。结论双气相配准定量CT对COPD进行影像学表型分型可为个体化诊断及治疗提供客观依据。
Purpose To identify the parameter differences of biphasic registration of quantitative CT in patients with type A, E and M of chronic obstructive pulmonary disease(COPD), and to analyze their correlations with pulmonary function(PF). Materials and Methods Eighty-seven patients with COPD underwent biphasic CT scanning, and the percent of low attenuation areas of inspiratory(%LAA-950 insp), the percent of low attenuation areas of expiratory(%LAA-856 exp), the percentage of area of emphysema(Emph%) and the thickness of bronchial wall were quantitatively measured. After that, results of type A, E and M were analyzed respectively. The quantitative parameters of CT(%LAA-950 insp, %LAA-856 exp, Emph%) and PF including FEV1%, forced expiratory volume in one second accounting for attenuation volume index forced vital capacity residual volume(FEV1/FVC), pulmonary diffusion capacity for carbon monoxide(DLCO), ratio of residual volume to total lung(RV/TLC) were studied, and the correlation between them was analyzed. Results There were statistically significance in difference of CT quantitative parameters and PF in patients with these three types of COPD(P<0.05). The parameters of %LAA-950 insp, %LAA-856 exp, Emph% and RV/TLC about the three types of COPD were shown in the order of A<E<M. As for the values of FEV1%, FEV1/FVC, DLCO, the order was A>E>M. For parameters of COPD-A, values of %LAA-950 insp and Emph% were not correlated with PF(P>0.05). %LAA-856 exp was negatively correlated with FEV1%, FEV1/FVC and DLCO, and positively correlated with RV/TLC(P<0.05). For COPD-E and COPD-M, values of %LAA-950 insp, %LAA-856 exp, Emph% were negatively correlated with FEV1%, FEV1/FVC, DLCO and positively correlated with RV/TLC(P<0.05). Conclusion Application of biphasic registration of QCT in imaging phenotype of COPD can provide clinical defining characteristics for individual diagnosis and treatment.
作者
赵凡惠
王雷
朱彦瑾
李建龙
郭佑民
黄晓旗
ZHAO Fanhui;WANG Lei;ZHU Yanjin;LI Jianlong;GUO Youmin;HUANG Xiaoqi(Department of Medical Imaging,the Affiliated Hospital of Yan’an University,Yan’an 716000,China)
出处
《中国医学影像学杂志》
CSCD
北大核心
2019年第11期829-833,共5页
Chinese Journal of Medical Imaging
基金
延安市科技攻关计划项目（2018KS-11）
延安市科技惠民计划（2017-HM-07-01）
关键词
肺疾病
慢性阻塞性
肺气肿
体层摄影术
螺旋计算机
图像处理
计算机辅助
呼吸功能试验
Pulmonary disease,chronic obstructive
Pulmonary emphysema
Tomography,spiral computed
Image processing,computer-assisted
Respiratory function tests
