摘要
分析和评估HCV与HBV共感染对HBV临床指征的影响。采集152例有静脉吸毒史HBV感染者血浆,其中HBV/HCV共感染组52例,HBV单感染组100例。检测分析包括ALT和AST、HBV表面抗原(HBsAg)、e抗原、e抗体、HBV DNA及anti-HCV IgG与HCV RNA。结果显示,两组样本的ALT和AST水平无显著差异(P=0.097,P=0.184);HBV/HCV共感染组HBsAg水平显著低于HBV单感染组HBsAg水平(P=0.020);共感染组HBV DNA阳性率显著低于HBV单感染组HBV DNA阳性率(P=0.004),且共感染组中HBV DNA载量也显著低于HBV单感染组HBV DNA载量(P=0.031)。进一步分析发现:在HBV单感染患者中的HBV DNA和HBsAg具有良好的正相关关系(r=0.752,P<0.001),但在HBV/HCV共感染患者中相关性减弱(r=0.387,P=0.042)。本研究显示HCV共感染可能与HBV存在竞争关系,从而影响HBV病毒复制水平及表面抗原分泌。
To analyze and evaluate the effect of HCV coinfection on clinical indicators of HBV-infected patients.152 individuals with HBV infection from intravenous drug users were enrolled.52 individuals were HBV/HCV co-infected and 100 individuals were mono-HBV infection.Serum ALT and AST,HBsAg,HBeAg,anti-HBe,HBV DNA and anti-HCV IgG,HCV RNA were measured.The results showed that there was no significant difference in ALT and AST levels between the two groups(P=0.097,P=0.184);The positive rate of HBV DNA in the co-infection group was lower(P=0.004)compared with mono-HBV infection,and the HBsAg level and HBV DNA load in co-infection group were lower than those of mono-HBV infection(P=0.020,P=0.031);there was a positive correlation between HBV DNA and HBsAg in mono-HBV infected individuals(r=0.752,P<0.001),but the correlation is weakened in coinfected individuals(r=0.387,P=0.042).The results of this study suggested HCV coinfection significantly impact HBV replication and HBsAg secretion,which may indicate that HCV coinfection interfere with HBV replication.
作者
张萍
刘文培
林应标
代国知
郭旺源
江杨华
唐萍
张健
瞿小旺
罗迪贤
ZHANG Ping;LIU Wenpei;LIN Yingbiao;DAI Guozhi;GUO Wangyuan;JIANG Yanghua;TANG Ping;ZHANG Jian;QU Xiaowang;LUO Dixian(Translational Medicine Institute,the First People’s Hospital of Chenzhou,University of South China,Chenzhou 423000,Hunan,China;Department of Laboratory Medicine,the First People’s Hospital of Chenzhou,Chenzhou 423000,Hunan,China)
出处
《中南医学科学杂志》
CAS
2019年第6期643-647,共5页
Medical Science Journal of Central South China
基金
湖南省临床医疗技术创新引导项目(2018SK50301,2018SK50304,2018SK50308)
