摘要
目的:分析动脉粥样硬化性脑梗死(atherosclerotic cerebral infarction,ASCI)患者血清超敏C反应蛋白(hypersensitive c-reactive protein,hs-CRP)、载脂蛋白-B(apolipoprotein-B,Apo-B)、氧化低密度脂蛋白(oxidized low-density lipoprotein,ox-LDL)及基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平与颈动脉粥样硬化性斑块(carotid atherosclerotic plaques,CAP)形成的相关性。方法:选取本院神经内科确诊的125例ASCI患者为观察组,另同期选取125例健康者为对照组。比较两组血清hs-CRP、Apo-B、ox-LDL及MMP-9水平,并对病例组行颈动脉超声检查,分析血清hs-CRP、Apo-B、ox-LDL及MMP-9水平与ASCI患者CAP形成的相关性。结果:与对照组相比较,观察组血清hs-CRP、Apo-B、ox-LDL及MMP-9水平显著升高(P<0.01)。观察组中伴CAP形成的患者血清hs-CRP、Apo-B、ox-LDL及MMP-9水平比无CAP形成的患者显著升高(P<0.01)。经多因素Logistic回归分析结果显示,血清hs-CRP(OR=4.76,95%CI:2.35~9.18)、Apo-B(OR=3.16,95%CI:1.59~7.32)、ox-LDL(OR=1.48,95%CI:1.15~2.01)及MMP-9(OR=3.86,95%CI:1.63~9.14)水平是ASCI患者CAP形成的独立危险因素(P<0.05)。结论:血清hs-CRP、Apo-B、ox-LDL及MMP-9的水平可反映ASCI患者CAP的炎症程度以及斑块的不稳定程度;ASCI患者血清hs-CRP、Apo-B、ox-LDL及MMP-9水平显著升高,其与ASCI患者CAP的形成密切相关,可作为临床诊断ASCI及CAP形成的重要血清学生物标志物。
Objective:To analyze the correlation between the levels of serum hypersensitive c-reactive protein(hs-CRP),apolipoprotein-B(Apo-B),oxidized low-density lipoprotein(ox-LDL)and matrix metalloproteinase-9(MMP-9)and carotid arteryplaque(CAP)in patients with atherosclerotic cerebral infarction(ASCI).Methods:125 patients with ASCI diagnosed in the Department of Neurology of Panzhihua Central Hospital from January 2018 to December 2018 were selected as the case group,and 125 healthy volunteers in the same period were selected as the control group.Serum levels of hs-CRP,Apo-B,ox-LDL and MMP-9 were compared between the two groups.Carotid ultrasound was performed in patients with ASCI.The correlation between serum levels of hs-CRP,Apo-B,ox-LDL and MMP-9 and the formation of CAP in patients with ASCI was analyzed by SPSS 23.0 statistics.Results:Compared with the control group,the levels of serum hs-CRP,Apo-B,ox-LDL and MMP-9 increased significantly in the case group(P<0.01).The serum levels of hs-CRP,Apo-B,ox-LDL and MMP-9 in patients with CAP were significantly higher than those without CAP in the case group(P<0.01).Multivariate logistic regression analysis showed that serum levels of hs-CRP(OR=4.76,95%CI:2.35-9.18),Apo-B(OR=3.16,95%CI:1.59-7.32),ox-LDL(OR=1.48,95%CI:1.15-2.01)and MMP-9(OR=3.86,95%CI:1.63-9.14)were independent risk factors for CAP formation in patients with ASCI(P<0.05).Conclusion:The contents of serumhs-CRP,Apo-B,ox-LDL and MMP-9 may reflect the serverity of inflammation and instability of carotid atherosclerotic plaque in ASCI patient.The levels of serum hs-CRP,Apo-B,ox-LDL and MMP-9 in patients with ASCI are significantly increased,which are closely related to the formation of CAP in patients with ASCI,so it can be used as important serum biomarkers for clinical diagnosis of ASCI and CAP formation.
作者
晏子俊
张良明
陈彦清
徐文豪
张月辉
兰玉平
袁晓燕
徐关丽
徐兴梦
YAN Zi-jun;ZHANG Liang-ming;CHEN Yan-qing;XU Wen-hao;ZHANG Yue-hui;LAN Yu-ping;YUAN Xiao-yan;XU Guan-li;XU xing-meng(Panzhihua central hospital,Sichuan panzhihua 617067,China)
出处
《海南医学院学报》
CAS
2019年第22期1713-1717,1722,共6页
Journal of Hainan Medical University
基金
心血管健康研究院-中国心血管健康联盟血脂异常及动脉粥样硬化研究基金(2017-CCA-Msdlipid-003)
四川省医学会高血压疾病(施慧达)专项科研课题(2018SHD2-7)~~
关键词
脑梗死
颈动脉粥样硬化性斑块
超敏C反应蛋白
载脂蛋白-B
氧化低密度脂蛋白
基质金属蛋白酶-9
Atherosclerotic cerebral infarction
Carotid arteryplaque
Hypersensitive c-reactive protein
Apolipoprotein-B
Oxidized low-density lipoprotein
Matrix metalloproteinase-9
