摘要
目的:研究探讨妥布霉素地塞米松眼膏辅助治疗睑板腺功能障碍性干眼症的效果。方法:选取2018年1-12月于本院眼科就诊的57例睑板腺功能障碍性干眼症患者为研究对象,按照随机数字表法分为试验组和对照组,试验组29例,对照组28例。两组均进行常规治疗,在此基础上,试验组采用妥布霉素地塞米松眼膏联合玻璃酸钠滴眼液治疗,对照组仅给予玻璃酸钠滴眼液治疗,比较两组患者治疗效果、干眼主观症状评分、睑板腺功能评分、泪膜破裂时间(BUT)、角膜荧光素染色(FL)、泪液分泌试验(SⅠt)及不良反应发生情况。结果:治疗后,试验组患者总有效率为96.55%,明显高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗后,试验组干眼主观症状评分、睑板腺功能评分均明显低于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组泪膜破裂时间、角膜荧光素染色及泪液分泌试验均明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:妥布霉素地塞米松眼膏辅助治疗睑板腺功能障碍性干眼症效果良好,可有效降低患者干眼主观症状评分及睑板腺功能评分,延长泪膜破裂时间,降低角膜荧光素染色得分,增加泪液分泌,降低患者不良反应发生率。
Objective: To investigate the effect of Tobramycin and Dexamethasone Ophthalmic Ointment in the adjuvant treatment of meibomain gland dysfunction dry eye disease. Method: A total of 57 patients with tarsal gland dysfunction xerophthalmia admitted to the ophthalmology department of our hospital from January 2018 to December 2018 were selected as research objects, according to the method of random number table, there were 29 cases in the experimental group and 28 cases in the control group. The experimental group was treated with Tobramycin and Dexamethasone Ophthalmic Ointment combined with Sodium Hyaluronate Eye Drops, and the control group was treated with Sodium Hyaluronate Eye Drops only.The treatment effect, subjective symptom score of dry eyes, meibomial gland function score, tear break-up time(BUT), corneal fluorescein staining(FL), schirmer Ⅰ test(SⅠt) and adverse reactions occur were compared between the two groups. Result: After treatment,the total effective rate in the experimental group was 96.55%, which was significantly higher than 75.00% in the control group, the difference was statistically significant(P<0.05). After treatment, the subjective symptom score and meibomini gland function score of the experimental group were significantly lower than those of the control group, with statistically significant differences(P<0.05). After treatment, the experimental group were significantly superior to the control group in BUT, FL and SⅠt, with statistically significant differences(P<0.05). After treatment, the incidence of adverse reactions in the experimental group was significantly lower than that in the control group(P<0.05). Conclusion: Tobramycin and Dexamethasone Ophthalmic Ointment has a good effect in the treatment of tarsal gland dysfunction xerophthalmia, it can effectively reduce the score of patients’ subjective symptoms of dry eyes and the score of meibomian gland function, prolong the tear film rupture time, reduce the score of corneal fluorescein staining, increase the tear secretion
作者
张倢
ZHANG Jie(Zhaoqing Gaoyao People’s Hospital,Zhaoqing 526040,China)
出处
《中国医学创新》
CAS
2019年第29期115-118,共4页
Medical Innovation of China
关键词
妥布霉素地塞米松
睑板腺功能障碍
干眼症
玻璃酸钠
Tobramycin and Dexamethasone
Meibomian gland dysfunctio
Xerophthalmia
Sodium Hyaluronate
