摘要
目的:探讨TLR4/MyD88信号通路在2型糖尿病合并慢性牙周炎发病中的作用。方法:选取2017-02—2018-02在我院内分泌科治疗的2型糖尿病患者157例,其中伴慢性牙周炎患者114例(合并组),单纯2型糖尿病患者43例(糖尿病组)。同期选取慢性牙周炎患者45例(慢性牙周炎组)和健康者40例(健康组)。收集临床资料,采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)检测血清中TLR4、MyD88、TNF-α、IL-1β和IL-6水平。结果:合并组和糖尿病组患者FG和HbAlc均高于慢性牙周炎组和健康组(P<0.05),而HDL-C低于慢性牙周炎组和健康组(P<0.05),合并组患者CRP高于糖尿病组、慢性牙周炎组和健康组(P<0.05);合并组牙齿数少于糖尿病组、慢性牙周炎组和健康组(P<0.05),合并组改良出血指数、PD和AL高于糖尿病组和健康组(P<0.05);合并组血清中TLR4、MyD88、TNF-α、IL-1β和IL-6水平均高于糖尿病组、慢性牙周炎组和健康组(P<0.05),糖尿病组和慢性牙周炎组血清中TLR4、MyD88、TNF-α、IL-1β和IL-6水平无差异(P>0.05),而均高于健康组(P<0.05)。结论:2型糖尿病合并慢性牙周炎患者血清中TLR4、MyD88、TNF-α、IL-1β和IL-6水平升高,TLR4/MyD88信号通路介导的炎症反应可能参与了该病的发生及病情进展。
Objective:To investigate the role of TLR4/MyD88 signaling pathway in the pathogenesis of type 2 diabetes mellitus with chronic periodontitis.Methods:A total of 157 patients with type 2 diabetes mellitus who were treated in our department were selected from February 2017 to February 2018,including 114 patients with chronic periodontitis(combined group)and 43 patients with type 2 diabetes alone(diabetes group).In the same period,45 patients with chronic periodontitis(chronic periodontitis group)and 40 healthy patients(healthy group)were selected.Clinical data was collected.The levels of TLR4,MyD88,TNF-α,IL-1βand IL-6 in serum were detected by enzyme linked immunosorbent assay(ELISA).Results:The FG and HbAlc in the combined group and the diabetes group were higher than those in the chronic periodontitis group and the healthy group(P<0.05),while the HDL-C was lower than that in the chronic periodontitis group and the healthy group(P<0.05),CRP in the combined group was higher than that in the diabetes group,chronic periodontitis group and healthy group(P<0.05).The number of teeth in the combined group was less than that in the diabetes group,chronic periodontitis group and healthy group(P<0.05).The modified bleeding index,PD and AL in the combined group were higher than those in the diabetes group and the healthy group(P<0.05).The levels of TLR4,MyD88,TNF-α,IL-1βand IL-6 in the serum in the combined group were higher than those in the diabetes group,chronic periodontitis group and healthy group(P<0.05).There were no significant differences in levels of TNF-α,IL-1βand IL-6 in serum between the diabetes group and the chronic periodontitis group(P>0.05),but which were higher than the healthy group(P<0.05).Conclusion:The levels of TLR4,MyD88,TNF-α,IL-1βand IL-6 in serum were elevated in patients with type 2 diabetes mellitus with chronic periodontitis.TLR4/MyD88 signaling pathway-mediated inflammation might be involved in onset and progression of the disease.
作者
汪晓龙
曹顺顺
张鹏
舒传继
WANG Xiao-long;CAO Shun-shun;ZHANG Peng;SHU Chuan-ji(Department of Stomatology,Edong Medical Group Huangshi Central Hospital,Hubei University of Technology Affiliated Hospital,Huangshi 435000,Hubei Province,China)
出处
《口腔颌面外科杂志》
CAS
2019年第1期39-43,共5页
Journal of Oral and Maxillofacial Surgery
