摘要
目的探讨羚贝止咳糖浆联合红霉素序贯治疗小儿支原体肺炎的临床疗效。方法将2017年2月至2018年5月收治的106例支原体肺炎患儿,按照治疗方法不同分为联合组(n=53)和对照组(n=53)。对照组采用红霉素序贯治疗。联合组在对照组基础上,采用羚贝止咳糖浆治疗。比较两组的疗效。记录两组的体温恢复正常时间、咳嗽消退时间、肺罗音消失时间、肺部阴影消失时间。检测两组C反应蛋白、白介素6、白介素8、肿瘤坏死因子α的水平。记录两组的不良反应发生情况。结果联合组的总有效率高于对照组,差异有统计学意义(94.34%vs 81.13%,P<0.05)。联合组的体温恢复正常时间、咳嗽消退时间、肺啰音消失时间、肺部阴影消失时间低于对照组,差异有统计学意义(P<0.01)。治疗后两组C反应蛋白、白介素6、白介素8、肿瘤坏死因子α显著降低,且联合组以上指标低于对照组,差异有统计学意义(P<0.05)。两组均无明显不良反应发生。结论羚贝止咳糖浆联合红霉素序贯治疗小儿支原体肺炎的疗效确切,并可明显降低炎症因子水平。
Objective To investigate the clinical effect of Lingbei Zhike syrup combined with erythromycin sequential therapy in the treatment of mycoplasma pneumonia in children.Methods A total of 106 children with mycoplasma pneumonia who received treatment from February 2017 to May 2018 were selected,and they were divided into combination group and control group(n=53,each).The control group was treated with erythromycin sequential therapy,and the combination group was treated with Lingbei Zhike syrup on the basis of the control group.The curative effect of the two groups was compared.The recovery time of body temperature,cough subsidence time,lung rale disappearance time and lung shadow disappearance time were recorded.The levels of C-reactive protein(CRP),interleukin(IL)-6,IL-8 and tumor necrosis factor(TNF)-α were measured.The adverse reactions of the two groups were recorded.Results The total effective rate of combination group was significantly higher than that of control group(94.34% vs 81.13%,P<0.05).The recovery time of body temperature,cough subsidence time,lung rale disappearance time and lung shadow disappearance time in the combination group were significantly lower than those in the control group(P<0.01).After treatment,CRP,IL-6,IL-8 and TNF-α in the two groups decreased significantly,and the above indexes in the combination group were lower than those in the control group(P<0.05).There were no obvious adverse reactions in both groups.Conclusion Lingbei Zhike syrup combined with erythromycin sequential treatment of mycoplasma pneumonia in children is effective.
作者
何茹
涂丹娜
王丽
姚凤芝
HE Ru;TU Dan-na;WANG Li;YAO Feng-zhi(Department of Paediatrics,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang,Hubei 441021,China)
出处
《中国临床研究》
CAS
2019年第11期1568-1570,共3页
Chinese Journal of Clinical Research
基金
湖北省自然科学基金(WJ2015MB121)~~
关键词
支原体肺炎
小儿
羚贝止咳糖浆
红霉素
序贯治疗
炎症因子
Mycoplasma pneumonia,children
Lingbei Zhike syrup
Erythromycin
Sequential therapy
Inflammatory cytokine
