摘要
Anti-Markovnikov hydroazidation of unactivated alkenes using ABX–N3 as an initiator has been developed at room temperature,wherein hydrogen azide(HN3)acts as both hydrogen and azidating agent.Notably,the HN3 reagent was generated from azidotrimethylsilane(TMSN3)and acetic acid in situ.The reaction itself displays broad substrate scope,good yields and excellent regioselectivities.
Anti-Markovnikov hydroazidation of unactivated alkenes using ABX–N3 as an initiator has been developed at room temperature,wherein hydrogen azide（HN3） acts as both hydrogen and azidating agent. Notably, the HN3 reagent was generated from azidotrimethylsilane（TMSN3） and acetic acid in situ. The reaction itself displays broad substrate scope, good yields and excellent regioselectivities.
基金
supported by the National Basic Research Program of China(973-2015CB856600)
the National Natural Science Foundation of China(21532009,21821002,21790330,21761142010)
the Science and Technology Commission of Shanghai Municipality(17XD1404500,17QA1405200,17JC1401200)
the strategic Priority Research Program(XDB20000000)
the Key Research Program of Frontier Science(QYZDJSSW-SLH055)of the Chinese Academy of Sciences
