摘要
发展了一种环境相对友好的、咪唑并吡啶衍生物和有机硒化合物C-3位的硒化反应,目标产物能以中等到优的收率获得.初步机理研究表明,该硒化反应经历了亲电加成反应机制,具有反应条件温和、底物范围宽泛、易于放大量生产等特点.因此,该策略在合成含氮和含硒分子中具有重要的应用前景.
An relative eco-friendly protocol for the direct C-3 selenation of imidazo[1,2-a]pyridines with vorious organoselenides has been developed,gaving the desired products in moderate to excellent yields.Preliminary experimental results are consistent with a C-3 electrophilic functionalization mechanism.The features with relative green reaction conditions,broad substrate scope,and easy scale-up operation would make this strategy promising and important for the preparation of nitrogen and selenium containing molecules.
作者
王薪
穆石强
孙婷
孙凯
Wang Xin;Mu Shiqiang;Sun Ting;Sun Kai(College of Chemistry and Chemical Engineering,Anyang Normal University,Anyang 455000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第10期2802-2807,共6页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(No.21801007)
the Program for Innovative Research Team of Science and Technology in the University of Henan Province(Nos.18IRTSTHN004,18HASTIT006)~~
关键词
硒化
咪唑并吡啶
C-3官能化
亲电机理
selenation
imidazo[1
2-a]pyridines
C-3 functionalization
electrophilic mechanism
