摘要
目的探讨血小板相关参数和凝血指标对肝硬化的检测价值。方法选择2016年5月—2017年5月厦门前埔医院收治的60例肝硬化患者作为肝硬化组,另选60例同期健康体检者作为健康对照组。采集所有受检者的血液标本,使用迈瑞BC-5380血细胞分析仪检测血小板相关参数〔包括血小板分布宽度(PDW)、血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)〕,使用雷杜RAC-050血凝仪检测凝血指标〔凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)〕。对比两组受检者的血小板相关参数和凝血指标的差异。结果肝硬化组PDW、PLT、MPV、PCT和FIB较健康对照组明显降低〔PDW(%):10.79±1.56比14.22±3.46,PLT(×10^9/L):89.12±14.22比189.44±21.89,MPV(fL):10.78±1.52比14.34±1.68,PCT(%):0.09±0.02比0.19±0.03,FIB(g/L):2.66±0.68比3.72±1.26,均P<0.05〕,但PT、APTT、TT却较健康对照组明显升高〔PT(s):18.44±2.64比12.66±4.69,APTT(s):45.26±7.94比34.68±5.66,TT(s):22.09±3.44比16.09±2.68,均P<0.05〕。结论血小板参数和凝血指标能够有效诊断和评价肝硬化患者病情,为临床诊疗奠定基础。
Objective To explore the detection values of platelet-related parameters and coagulation indexes for cirrhosis.Methods Sixty patients with cirrhosis admitted to Qianpu Hospital in Xiamen from May 2016 to May 2017 were selected as the cirrhosis group,and other 60 healthy people who underwent physical examinations at the same period were selected as the healthy control group.Blood samples were collected from all the subjects,Mindray BC-5380 blood cell analyzer was used to detect the platelet related parameters[including platelet distribution width(PDW),platelet count(PLT),mean platelet volume(MPV)and thrombocytocrit(PCT)],and Rayto RAC-050 blood coagulation instrument was applied to detecting the blood coagulation indexes[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT)and fibrinogen(FIB)].The differences in platelet-related parameters and coagulation indexes between the two groups were compared.Results The PDW,PLT,MPV,PCT and FIB levels were significantly lower in liver cirrhosis group than those in healthy control group[PDW(%):10.79±1.56 vs.14.22±3.46,PLT(×10^9/L):89.12±14.22 vs.189.44±21.89,MPV(fL):10.78±1.52 vs.14.34±1.68,PCT(%):0.09±0.02 vs.0.19±0.03,FIB(g/L):2.66±0.68 vs.3.72±1.26,all P<0.05],but the PT,APTT and TT levels were significantly higher in liver cirrhosis group than those in healthy control group[PT(s):18.44±2.64 vs.12.66±4.69,APTT(s):45.26±7.94 vs.34.68±5.66,TT(s):22.09±3.44 vs.16.09±2.68,all P<0.05].Conclusion The platelet-related parameters and coagulation indexes can effectively help to diagnose and evaluate the disease condition of patients with cirrhosis,and lay a foundation for the clinical diagnosis and treatment.
作者
黄远兴
Huang Yuanxing(Department of Laboratory,Xiamen Qianpu Hospital,Xiamen 361008,Fujian,China)
出处
《实用检验医师杂志》
2019年第3期141-142,共2页
Chinese Journal of Clinical Pathologist
关键词
肝硬化
血小板参数
凝血指标
检测价值
Liver cirrhosis
Platelet parameters
Coagulation index
Test value
