摘要
目的探讨噻托溴铵联合沙美特罗对慢性阻塞性肺疾病(COPD)患者运动耐量及肺功能的影响。方法选取2017年3月~2018年12月我院收治的90例COPD患者作为研究对象,按照随机数字表法分为对照组与研究组,每组各45例。对照组患者给予吸入沙美特罗替卡粉吸入剂治疗,研究组患者在对照组的基础上联合噻托溴铵吸入粉雾剂治疗。比较两组患者的临床疗效、运动耐量、肺功能和用药安全性。结果研究组患者的治疗总有效率为88.89%,高于对照组的68.89%,差异有统计学意义(P<0.05);研究组患者6 min行走距离(6MWD)长于对照组,最大肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论噻托溴铵联合沙美特罗可有效增强COPD患者的运动耐量,改善肺功能,安全性较高。
Objective To investigate the effects of Tiotropium Bromide combined with Salmeterol on exercise tolerance and lung function in patients with chronic obstructive pulmonary disease(COPD).Methods Ninety patients with COPD treated in our hospital from March 2017 to December 2018 were selected as the subjects.They were divided into control group and study group according to the random number table method,with 45 cases in each group.The control group was given inhaled Salmeterol Inhalation Powder Inhalation,and the study group was treated with Inhaled Tiotropium Inhalation Powder on basis of the control group.The clinical efficacy,exercise tolerance,lung function and medication safety were compared between the two groups.Results The total effective rate of the study group was 88.89%,higher than 68.89%of the control group,and the difference was statistically significant(P<0.05).The 6-min walking distance(6MWD)in the study group was longer than that in the control group,the maximum vital capacity(FVC),forced expiratory volume in the first second(FEV1)and FEV1/FVC were higher than those in the control group,and the differences were statistically significan group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Tiotropium Bromide combined with Salmeterol can effectively enhance exercise tolerance,improve lung function,and have higher safety in patients with COPD.
作者
陈岚兰
庄其宏
CHEN Lan-lan;ZHUANG Qi-hong(Department of Respiratory Medicine,the First Affiliated Hospital of Xiamen University,Fujian Province,Xiamen 361003,China)
出处
《中国当代医药》
2019年第30期71-74,共4页
China Modern Medicine
关键词
慢性阻塞性肺疾病
噻托溴铵
沙美特罗
运动耐量
肺功能
Chronic obstructive pulmonary disease
Tiotropium Bromide
Salmeterol
Exercise tolerance
Lung function
