摘要
全球炎症性肠病(IBD)的患病率明显上升。在传统治疗药物不良反应较大,生物制剂、免疫抑制剂价格昂贵的情况下,寻求安全有效的益生菌辅助治疗以提高传统药物的疗效,或可成为减轻患者负担、提高患者生活质量的可靠途径。布拉酵母菌(S. boulardii)作为一种益生菌,使用历史悠久,在结肠炎症的动物模型和临床试验中表现出一定的有效性。本文就S. boulardii在IBD中的治疗作用及其机制作一综述。
The prevalence of inflammatory bowel disease (IBD) has increased significantly worldwide. Under the situation that some conventional drugs have significant side effects, and biological and immunosuppressive agents are expensive, exploring the safe and effective probiotics to improve the effect of traditional drugs may become a reliable way to ease the economic burden of patients and improve the quality of life. As a probiotic, Saccharomyces boulardii has a long history of use, and has shown some effectiveness in animal models with colitis and in clinical trials. This article reviewed the therapeutic effect and mechanism of Saccharomyces boulardii on IBD.
作者
冉丹
张振玉
RAN Dan;ZHANG Zhenyu(Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing (210000))
出处
《胃肠病学》
2019年第9期561-564,共4页
Chinese Journal of Gastroenterology
关键词
炎症性肠病
布拉酵母菌
治疗
机制
Inflammatory Bowel Disease
Saccharomyces boulardii
Therapy
Mechanisms
