摘要
本文回顾并讨论脑红蛋白的生物学功能以及其在癫痫中的神经保护作用及具体机制。脑红蛋白主要参与神经干细胞的增殖、促进轴突再生并减轻氧化应激水平、调控细胞凋亡及自噬途径,从而缓解神经元的急性损伤。在癫痫中发挥神经保护的具体机制:调节Pik3k/Akt信号通路、Jak2/Stat3途径以及抑制caspase-3活性,与促红细胞生成素受体协调共同启动有关信号转导途径。本文为预防癫痫引起的神经元细胞死亡和治疗癫痫引起的脑损伤提供了新思路。
This study reviews and discusses the biological functions of neuroglobin and the neuroprotective effects of neuroglobin in epilepsy and its specific mechanisms.Neuroglobin is mainly involved in the proliferation of neural stem cells,promoting axonal regeneration and reducing oxidative stress levels,regulating apoptosis and autophagy pathways,thereby alleviating acute neuronal damage.The specific mechanism of neuroprotection of neuroglobin in epilepsy is regulating the Pik3k/Akt signaling pathway,the Jak2/Stat3 pathway,and the inhibition of activation of caspase-3 activity,and cooperating with the erythropoietin receptor to initiate the relevant signal transduction pathway.This review provides new ideas for preventing the death of neuronal cells caused by epilepsy and reference for treating brain damage caused by epilepsy.
作者
杜欢
弥曼
郭向阳
刘曼玲
刘娜
DU Huan;MI Man;GUO Xiangyang;LIU Manling;LIU Na(Graduate School,Xi'an Medical University,Shaanxi Province,Xi'an 710021,China;Institute of General Medicine,Xi'an Medical University,Shaanxi Province,Xi'an 710021,China;Department of Pediatrics,Shaanxi Provincial People's Hospital,Shaanxi Province,Xi'an 710068,China)
出处
《中国医药导报》
CAS
2019年第28期67-70,共4页
China Medical Herald
基金
陕西省社会发展科技攻关项目（2016SF-344）
关键词
脑红蛋白
神经保护
癫痫
脑损伤
Neuroglobin
Neuroprotective
Epilepsy
Brain damage
