摘要
目的探讨注射用红花黄色素治疗急性脑梗死(AIS)的临床效果。方法选取2017年1月~2018年12月上饶市立医院神经内科收治的60例AIS患者作为研究对象,采用随机数字表法将其分为对照组与观察组,每组各30例。对照组患者采用常规治疗,观察组在对照组的基础上予以注射用红花黄色素治疗。比较两组患者的临床疗效,根据美国国立卫生研究院卒中量表(NIHSS)和患者自理能力评估量表(Barthel指数)评估两组患者治疗前后的神经功能缺损情况以及自理能力,并比较两组患者治疗前后的血浆全血黏度(ηb)以及血浆黏度(ηp)血液流变学指标以及两组治疗期间出现的不良反应总发生率。结果观察组患者的治疗总有效率(86.67%)与对照组(73.33%)比较,差异无统计学意义(P>0.05);观察组患者治疗后的NIHSS评分低于对照组,Barthel指数高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的ηb和ηp水平均低于对照组,差异有统计学意义(P<0.05);观察组患者的不良反应总发生率(6.67%)与对照组(16.67%)比较,差异无统计学意义(P>0.05)。结论注射用红花黄色素治疗AIS能够降低患者的神经功能缺损程度,提高患者的生活自理能力,改善其血液流变学水平。
Objective To investigate the clinical effect of Safflower Yellow Pigment for injection in the treatment of acute ischemic stroke(AIS).Methods A total of 60 AIS patients who were treated in Neurology Department of Shangrao City Hospital from January 2017 to December 2018 were selected as the subjects.They were divided into control group and observation group by random number table method,with 30 cases in each group.The control group received routine treatment,and the observation group received Safflower Yellow Pigment for injection on the basis of the control group.The clinical efficacy between the two groups was compared.National Institutes of Health Stroke Scale(NIHSS)and self-care ability assessment scale(Barthel index)were performed to assess nerve function defects and self-care ability in both groups before and after treatment.The hemorheology indexes such as plasma whole blood viscosity(ηb)and plasma viscosity(ηp)before and after treatment were compared between the two groups,and the total incidence of adverse reactions during treatment was compared between the two groups.Results The total treatment effect rate in the observation group(86.67%)and control group(73.33%)was not statistically significant(P>0.05).After treatment,NIHSS score in the observation group was lower than that in the control group,while Barthel index was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,levels ofηb andηp in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence rates of adverse reactions in observation group(6.67%)and control group(16.67%)was not statistically significant(P>0.05).Conclusion Safflower Yellow Pigment for injection in treatment of AIS can reduce nerve function defect degree,improve self-care ability,and improve hemorheology level.
作者
赵超
ZHAO Chao(Department of Neurology,Shangrao Municipal Hospital,Jiangxi Province,Shangrao 334000,China)
出处
《中国当代医药》
2019年第31期49-52,共4页
China Modern Medicine
关键词
急性脑梗死
红花黄色素
临床效果
安全性
Acute ischemic stroke
Safflower Yellow Pigment
Clinical effect
Safety
