摘要
目的研究多索茶碱在慢性阻塞性肺疾病(以下简称慢阻肺)急性加重恢复期中作用,降低早期再发风险.方法选取滨州市中心医院2016年1月至2018年1月收治的慢阻肺急性加重治疗缓解患者共164例,随机数字表法分为对照组和观察组各82例.对照组给予吸入噻托溴铵和布地奈德/福莫特罗,观察组在吸入药物基础上给予口服多索茶碱联合治疗8周,观察两组恢复期时间、再次急性加重发生率、第一秒用力呼气量(FEV1)占预计值的百分比(FEV1%)、慢性阻塞性肺疾病评估测试量表(CAT)评分和6分钟步行试验.结果观察组恢复期时间短于对照组[(16.89±5.15)d比(19.12±6.29)d,t=2.48,P=0.014)],再次急性加重发生率低于对照组(26.83%比41.46%,χ^2=4.58,P=0.032),两组FEV1%差异无统计学意义[(45.59±9.82)%比(44.26±9.03)%,t=0.90,P=0.369)],CAT评分优于对照组[(19.32±6.16)分比(21.71±6.62)分,t=2.39,P=0.018],6分钟步行距离远于对照组[(146.32±10.20)m比(135.69±11.59)m,t=6.23,P=0.000)],指脉氧(SpO2)高于对照组[(94.12±5.09)%比(92.06±6.21)%,t=2.23,P=0.026)],呼吸频率慢于对照组[(20.38±7.32)次/min比(22.86±6.53)次/min,t=2.29,P=0.023)],两组心率差异无统计学意义[(98.24±12.35)次/min比(101.38±15.03)次/min,t=1.46,P=0.146)],两组均未发现严重药物不良反应.结论多索茶碱在慢阻肺急性加重恢复期作为吸入药物的有益补充,可缩短恢复期时间,降低早期急性加重发生率,改善症状.
Objective To study the effect of doxofylline on acute exacerbation of chronic obstructive pulmonary disease(COPD)and reduce the risk of early recurrence.Methods From January 2016 to January 2018,164 patients with acute exacerbation of COPD in Binzhou Central Hospital were randomly divided into two groups by random digital table:control group(n=82)and observation group(n=82).The control group was given tiotropium bromide and budesonide/formoterol.The observation group was treated with oral doxophylline bid for 8 weeks on the basis of inhaled drugs.The recovery time,acute exacerbation rate,FEV1,CAT score and 6-minute walking test were compared between the two groups.Results The time of convalescent stage in the observation group was shorter than that in the control group[(16.89±5.15)d vs.(19.12±6.29)d,t=2.48,P=0.014],and the acute exacerbation rate of the observation group was lower than that of the control group(26.83%vs.41.46%,χ^2=4.58,P=0.032).There was no statistically significant difference in FEV 1[(45.59±9.82)%vs.(44.26±9.03)%,t=0.90,P=0.369],and the CAT score of the observation group was better than that of the control group[(19.32±6.16)points vs.(21.71±6.62)points,t=2.39,P=0.018].The 6-minute walking distance of the observation group was longer than that of the control group[(146.32±10.20)m vs.(135.69±11.59)m,t=6.23,P=0.000],and the finger pulse oxygen of the observation group was higher than that of the control group[(94.12±5.09)%vs.(92.06±6.21)%,t=2.23,P=0.026].The respiratory rate in the observation group was slower than that in the control group[(20.38±7.32)times/min vs.(22.86±6.53)times/min,t=2.29,P=0.023],and there was no statistically significant difference in heart rate[(98.24±12.35)bpm vs.(101.38±15.03)bpm,t=1.46,P=0.146].No serious adverse drug reactions were found in both two groups.Conclusion As a beneficial supplement of inhaled drugs in convalescent COPD,doxofylline can shorten the recovery time,reduce the early acute exacerbation rate and improve the symptoms,which is worthy o
作者
张学平
张莹
马小芬
李新
胡振彩
翟云青
Zhang Xueping;Zhang Ying;Ma Xiaofen;Li Xin;Hu Zhencai;Zhai Yunqing(Department of Respiratory Medicine,Binzhou Central Hospital,Binzhou,Shandong 251700,China)
出处
《中国基层医药》
CAS
2019年第21期2588-2592,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肺疾病
慢性阻塞性
用力呼气量
多索茶碱
Pulmonary disease
chronic obstructive
Forced expiratory volume
Doxofylline
