摘要
目的评估妊娠早期维生素E联合空腹血糖(FPG)对妊娠期糖尿病发生风险的临床预测价值。方法选择2018年9月-2019年2月在郑州大学第三附属医院建卡,并在孕24周~28周确诊妊娠期糖尿病的患者120例为妊娠期糖尿病组,随机选取同期正常健康孕妇126例,作为对照组。分析两组临床基本资料、孕早期维生素E及FPG等参数;并采用多因素Logistic回归分析确定妊娠期糖尿病发生独立危险因素,绘制受试者工作曲线(ROC),记录曲线下面积(AUC)分析维生素E及FPG预测妊娠期糖尿病发生的临床价值。结果 GDM组维生素E,孕早期空腹血糖水平明显高于对照组,差异有统计学意义(P<0.05)。Logistic回归分析结果显示:维生素E、妊娠早期空腹血糖是GDM的发生的独立危险因素。ROC曲线分析表明:维生素E及孕早期FPG用于预测妊娠期糖尿病的AUC分别为0.621,0.666,联合预测妊娠期糖尿病的AUC为0.707。结论尽管早孕期孕妇外周血中维生素E,FPG是GDM发生的独立危险因素,但维生素E对GDM的预测准确性较低,维生素E联合孕早期空腹血糖对GDM的预测有一定的准确性。
Objective To evaluate the clinical prediction value of the risk of diabetic diabetes in gestational diabetes by evaluating the early vitamin E combined fasting blood-glucose(FPG).Methods A total of 120 patients with(GDM) were selected as gestational diabetes mellitus(GDM)group, from September 2018 to February 2019, who were diagnosed as gestational diabetes mellitus(GDM),in the third affiliated hospital of zhengzhou university, and 126 cases of normal healthy pregnant women were randomly selected as control group.The clinical basic data of the two groups, vitamin E and the parameters of FPG in early pregnancy were analyzed. And using the multivariate logistic regression analysis to determine the independent risk factors of gestational diabetes, the clinical values of the vitamin E and the parameters of FPG in predicting gestational diabetes mellitus(GDM)in early pregnancy was analyzed by AUC.Results The values of vitamin E and FPG in gestational diabetes mellitus(GDM)group were significantly higher than those in control group(P<0.05). Vitamin E and FPG were independent risk factors of gestational diabetes mellitus(GDM)in early pregnancy. ROC curve analysis showed that the AUC of FPG and Vitamin E in predicting gestational diabetes mellitus were 0.621,0.666. The AUC of the combined prediction of gestational diabetes was 0.707.Conclusion Although the vitamin E, FPG in the peripheral blood of pregnant women is an independent risk factor for GDM, vitamin E is low in prediction of GDM, the combination of Vitamin E and FPG in early pregnancy has certain accuracy in the prediction of diabetes mellitus.
作者
苏红莉
徐冬梅
陈桂霞
张丽
乔天義
崔玲玲
SU Hong-li;XU Dong-mei;CHEN Gui-xia;ZHANG Li;QIAO Tian-xi;CUI Ling-ling(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《医药论坛杂志》
2019年第10期12-16,共5页
Journal of Medical Forum
基金
中国疾病预防控制中心妇幼保健中心科研项目(2019FYH004)
关键词
妊娠期糖尿病
维生素E
空腹血糖
Gestational diabetes mellitus
Vitamin E
Fasting blood glucose
